The effect of time-of-day and chest physiotherapy on multiple breath washout measures in children...

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The effect of time-of-day and chest physiotherapy on multiple breath washout measures in children with clinically stable cystic fibrosis by Mind Map: The effect of time-of-day and chest physiotherapy on multiple breath washout measures in children with clinically stable cystic fibrosis

1. Introduction

1.1. We are trying to investigate daytime variation of multiple breath nitrogen washout measure in children with clinically stable cystic fibrosis. An interesting facts about this experiment is that it hasn't been tested on anyone (the effect of time-of-day and chest physiotherapy on multiple breath washout measures in children with clinically stable cystic fibrosis).

2. Methods

2.1. Ten school children with Cystic Fibrosis were chosen and performed multiple breath nitrogen washout (N2MBW) followed by spirometry (common test used to assess how well your lungs work by measuring how much air you inhale, how much you exhale, and how quickly you exhale) and plethysmography (an instrument for measuring changes in volume within an organ or whole body) in the morning and afternoon at three visits (that were one month apart). Immediately before the afternoon measurements at visit 2, a chest physiotherapy was performed. Also, immediately before morning and afternoon measurements at visit 3, another chest physiotherapy was performed. A linear mixed models were used to evaluate the influence of time-of-day and chest physiotherapy measurement.

3. Results

3.1. There were sufficient data from 8 children (median age range: 9.6) . The baseline lung clearance index (LCI) was 9.0 and baseline FEV% predicted was 97.5. The multiple breath nitrogen washout measures weren't significantly influenced by time-of-day or chest physiotherapy. The baseline lung clearance index decreased non-significantly 5% (-0.32; 0.22)) during the day. After chest physiotherapy, the baseline lung clearance index increased non-significantly 8% (-0.26;0.42). All spirometric measures were unaffected by time-of-day and chest physiotherapy.

4. Discussion

4.1. This experiment concluded that the time-of-day as chest physiotherapy performed immediately prior to multiple breath nitrogen washout had no significant influence on multiple breath nitrogen washout measures.

5. Background Information on Cystic Fibrosis

5.1. Cystic Fibrosis, known as CF, is an inherited disease. This disease is a genetic disorder, which is a defective gene from each parents. The CF gene is most often found in mothers since men with CF may be sterile. CF causes defect in certain cells of the lung and digestive systems. This defect creates the cell to produce a thick, mucus. Once the cell produces the thick mucus, it causes blockage in the lung and airways. Also, it causes problems digesting and absorbing nutrients. There isn't a cure for CF, but treatments is provided. The treatments tries to improve the amount of nutritions your body receives, preventing and treating lung and sinus infections, and keeping the airways and lung as clear as possible.