RESISTENCIA ANTIRRETROVIRAL

Get Started. It's Free
or sign up with your email address
Rocket clouds
RESISTENCIA ANTIRRETROVIRAL by Mind Map: RESISTENCIA ANTIRRETROVIRAL

1. Tropismo CCR5 o CXCR4

2. ITRAN

2.1. R. Alta

2.1.1. TDF/TAF, ABV

2.1.1.1. K65R

2.1.1.2. Q151L/M complejo para ABV

2.1.2. FTC/3TC

2.1.2.1. M184V/I

2.1.3. AZT

2.1.3.1. T215Y/F

2.1.3.2. Q151L/M complejo

2.2. R. Intermedia

2.2.1. AZT

2.2.1.1. <3TAMs

2.2.2. ABV

2.2.2.1. K70E/G L74I/V Y115F M184V <3 TAMs

2.2.3. TDF/TAF

2.2.3.1. K70E/G Q151L/M Complejo 3 TAMs

2.2.4. FTC/3TC

2.2.4.1. K65R Q151L/M Complejo

2.3. Hipersusceptibilidad

2.3.1. AZT

2.3.1.1. K65R, E70E/G M184I/V K65R+M184I/V

2.3.2. TDF/TAF

2.3.2.1. M184I/V

3. ITRANN

3.1. Resistencia

3.1.1. NVP

3.1.1.1. L100I, K101E/P,K103H/A/S/T, V106A/M, Y181C/I/S/V, Y188C/H/L, G190A/C/E/Q/S/T/V, F227C/L, M230L

3.1.2. EFV

3.1.2.1. L100I, K101P, K103H/A/S/T, V106A/M, Y181C/I/S/V, Y188C/H/L, G190A/C/E/Q/S/T/V, F227C/L, M230L

3.1.3. ETV

3.1.3.1. K101P, Y181C/I/V, >3 (L101I, K101E/H/I/R, V106I, G190A/S, M230L)

3.1.4. RPV

3.1.4.1. L100I, K101P, Y181C/I/V, Y188L, M230I/L/V

3.2. R. Intermedia

3.2.1. NVP

3.2.1.1. A98G, K101E, H221Y

3.2.2. EFV

3.2.2.1. P255H

3.2.3. ETV

3.2.3.1. L100I , 2(K101E/H/I/P/R, V106I, G190A/S) Y188L, M230L, F227C

3.2.4. RPV

3.2.4.1. K101G, E138A/K, V179L, H221Y, F227C

4. I. Proteasa

4.1. Resistencia

4.1.1. LPV/RTV

4.1.1.1. I47A, L76V, V82A/F/S/T, >4L10F,/I/R/V, K20M/R, L24I,, V32I, L33F, M46I/L, G48V/M, I50V, F53L, I54M/L/T/V/A, L63P, A71I/L/V/T, G735, I74V, L90L)

4.1.2. ATV/RTV

4.1.2.1. I50L, I84V, >3 (L10F/I/R/V, G16E, K20M/R/I/T/V, L24I, V32I, L33F/I/V, M46I/L, I47V, G48V/M, F53L, I54V/T/A/L/M, D60E, A71V/T, G73C/S/T/A, V82A/F/S/T, I83V, L90M)

4.2. R. Intermedia

4.2.1. DRV/RTV

4.2.1.1. >4 (V11I, V32I, L33F, I47V/A, I50V, I54L/M, T74P, L76V, V82F, I84V, L89V)

4.2.2. LPV/RTV

4.2.2.1. 3 (L10F,/I/R/V, K20M/R, L24I, V32I, L33F, M46I/L, G48V/M, I50V, F53L, I54M/L/T/V/A, L63P, A71I/L/V/T, G73S, I84V, L90M)

4.2.2.1.1. ,

4.2.3. ATV/RTV

4.2.3.1. 2 (L10F/I/R/V, G16E, K20M/R/I/T/V, L24I, V32I, L33F/I/V, M46I/L, I74V, G48V/M,F53L, I54V/T/A/L/M, D60E, A71V/T, G73C/S,/T/A, V82A/T/S/T, I85V, L90M)

4.2.4. DRV/RTV

4.2.4.1. 3 (V11I, V32I, L33F, I47V/A, I50V, I54L/M, T74P, L76V, V82F, I84V, L89V)

4.3. Hipersusceptibilidad

4.3.1. LPV/RTV

4.3.1.1. I50L

4.3.2. ATV/RTV

4.3.2.1. L76V

4.3.3. DRV/RTV

4.3.3.1. I50L, N58S

5. I. Integrasa

5.1. Resistencia

5.1.1. RTG

5.1.1.1. T66K, E92Q/V, F121Y, Y143C/H/R, Q148H/K/R, N155H

5.1.2. EVG

5.1.2.1. T66A/K/I, E92GQV, F121Y, S147G, Q148H/K/R, N155H, R263K

5.1.3. DTG

5.1.3.1. Q148H/K/R+>2 (G140A/C/S, E138A/K/T o L74I)

5.2. R. Intermedia

5.2.1. RTG

5.2.1.1. H51Y, T66AI, E92G, E38A/K, G140A/C/S, G163R, S230R, R263K)

5.2.2. EVG

5.2.2.1. H51Y, E138A/K,G140A/C/S, G163R, S230R

5.2.3. DTG

5.2.3.1. Q148H/K/R+1(G140A/C/S, E138A/K/T o L74I), R263K

6. Antagonistas de CCR5

7. TAMs: M41L, D67N, K70R, L210W, T215F/Y, K219Q/E

8. Q151L/M complejo: A62V, V75I, F77L, F116Y, Q151L/M

9. BIBLIOGRAFIA: Guía de Resistencias a los Antirretrovirales: Actualización 2018; Red de Investigación en SIDA (RIS), 1-13