Digoxin

1. Different dosage forms available in the Omani market

1.1. Tablets

1.2. Injection .. ministerial only

2. contraindication

2.1. Hypersensitivity to digoxin or any of its elements.

2.2. A history of patients with digoxin poisoning.

2.3. Ventricular tachycardia or ventricular fibrillation

3. Two brand names, strength and route of administration

3.1. In Oman: Lanoxin, 0.25mg , Orally, Tablets.

3.2. international brand: Digox, 0.125mg , Orally, Tablets.

4. Most important Pharmaceutical uses

4.1. atrial fibrillation

4.2. heart failure

5. ADME

5.1. Digoxin is well absorbed in the gastrointestinal tract. Oral bioavailability Digoxin is usually high (70% -80%). Digoxin contains a large amount of distribution, due to its high convergence in the structural muscles, heart, intestines and kidneys. A small portion of digoxin is metabolized by the liver and undergoes approximately 8% intestinal gastrointestinal circulation. Half-life Elimination of long digoxin.

6. Side effects

6.1. Belly pain

6.2. Anorexia

6.3. Visual Disorders (all yellow)