Toxicological Tests

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Toxicological Tests by Mind Map: Toxicological Tests

1. Acute

1.1. Focus on determining the short-term adverse effects of a drug when administered in a single dose, or in multiple doses during a period of 24 hrs in two mammalian species.

1.2. Fixed dose method (OECD 420)

1.3. Up and down method (OECD 425)

1.4. Acute toxic class method (OECD 423)

2. Ocular

2.1. Study acute eye irritation/corrosion

2.2. (OECD 405) preferentially in vitro

3. Dermal

3.1. This tests are intended to characterize irritation potential, cutaneous and/or systemic toxicity associated with topical administration of compounds

3.2. Daize test

3.3. In vivo

3.4. Corrositex

3.5. Trascutaneous Electrical Resistance (TER)

4. Long-Term

4.1. Determinates whether there is any cancinogenic potential focussing on non-genotoxic cacinogens that cannot be detected in the short-term test methods.

4.2. Carciogenic tests

5. Respiratory irritation

5.1. Test done by one dosage exposure follow examination of inflammation of tissue of respiratory tract

5.2. Acute Inhalation Toxiocology (OECD 403)

6. Genetic

6.1. Screen for a certain chemical being toxic and chemical genotypic carcinogens (cancer creating)

6.2. Bacterial Mutation Assays

6.3. Mammalian Cell Mutation (OECD 476)

6.4. Chromosomal Mutation

6.5. Bone Marrow Cytogenic Test (OECD 475)

6.6. Micronucleus Test (OECD 474)

6.7. DNA Damage Test

7. Allergic Reactions

7.1. Scale allergic potential of chemical

7.2. Skin Sensitisation studies (OECD 406)

7.2.1. Buehler test

7.2.2. Guinea Pig Maximisation GMPT

7.3. Respiratory Sensitisation

7.3.1. Pulmonary Response detection in guinea pigs and IgE measurements in mice Structure activity relationships

8. Short Term Sub Acute/ Sub Chronic

8.1. Investigate adverse effects of repeated exposure of a chemical of a smaller dosage >10% of lifespan

8.1.1. (Sub acute) Rat test, 14-28 day duration (Sub chronic) Rat test, bare min. 90 day duration

9. Reproductive

9.1. Single or multi generation studies to determine disturbances due to chemical exposure of respectively one and two generations