Types of hypersensitivity reactions

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Types of hypersensitivity reactions by Mind Map: Types of hypersensitivity reactions

1. Allergy and Atopy

1.1. IgE

1.1.1. bound to mast cells and basophils

1.1.2. release of vasoactive mediators

1.1.2.1. Hay fever

1.1.2.2. Asthma

2. Antibody-mediated hypersensitivity

2.1. IgG

2.1.1. IgM

2.1.2. Ab directed against cell surface antigens

2.1.2.1. mediates cell destruction

2.1.2.1.1. complement activation

2.1.2.1.2. ADCC.

3. Immune complex-mediated hypersensitivity

3.1. Immune complexes

3.1.1. Ag-Ab complexes deposited in various tissues induce complement activation

3.1.2. ensuing inflammatory response

3.1.2.1. massive infiltration of neutrophils.

3.1.2.1.1. Rheumatoid arthritis

3.1.2.1.2. Systemic lupus

4. Delayed type hypersensitivity (DTH)

4.1. T cells

4.2. release cytokines

4.2.1. macrophages

4.2.2. Tc cells

4.2.3. direct cellular damage

4.2.3.1. Tuberculin

4.2.3.2. Multiple sclerosis