Hypertension Medications

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Hypertension Medications by Mind Map: Hypertension Medications

1. Diuretics

1.1. Thiazides

1.1.1. Prevent kidney Na+/water reabsorption in distal diluting tubules

1.1.2. SE: hyponatremia, hypokalemia, hypercalcemia, hyperglycemia, hyperurecemia

1.2. Loop

1.2.1. Inhibits water transport across loop of henle

1.2.2. SE: volume depletion, hypokalemia/natremia/calcemia

1.2.3. CI: sulfa allergy

1.3. K+ Sparing

1.3.1. Inhibits aldosterone mediated Na+/H20 absorption

1.3.2. SE: hypercalemia

1.3.3. CI: renal failure, hyponatremia


2.1. Indications: HTN esp if DM, nephropathy (renoprotective), CHF, post MI

2.2. MOA: decrease preload/afterload, decrease synthesis of AG II/aldosterone

2.3. SE: first dose hypotension, azotemia/renal insufficiency, cough and angioedema

3. ARBs

3.1. Ind: if not able to tolerate BB/ACEI

3.2. Blocks EFFECT of AG II (not production)

4. CCB

4.1. Dihydropyridine

4.1.1. Vasodilator w/ little effect on cardiac contractility or condution

4.1.2. Nifedipine, Amlodipine

4.2. Non-dihydropyridines

4.2.1. Affect Cardiac contractility and conduction

4.2.2. Used when concomitant Afib

4.2.3. Verapamil, Diltiazem

4.3. Indications: Raynaud's, angina, HTN

4.4. SE: HA, dizziness, lightheadedness, flushing, PERIPHERAL EDEMA

4.5. CI: 2nd/3rd degree heart block, CHF

5. BB

5.1. Ind: HTN especially if hx of MI or tachycardia, angina, acute MI, heart failure, migraines, essential tremors, pheochromocytoma

5.2. NOT monotherapy first line

5.3. SE: fatigue, depression, impotence, masks sympathetic sx of hypoglycemia

5.4. CI: 2nd/3rd degree heart block, decompensated heart failure, asthma/COPD w/ nonslelective agents, may worsen Raynauds/peripheral vascular dz

5.5. Cardioselective: Esmolol, metoprolol, atenolol Nonselective: propranolol Both: Carvedilol, labetalol

6. Alpha 1 Blockers

6.1. Good for hypertensive w/ BPH

6.2. SE: 1st dose syncope, dizziness, HA

6.3. NOT used first line

6.4. Prazosin, Terazosin, Doxazosin