1. Locally malignant tumors
1.1. Basal Cell Carcinoma
1.1.1. Site : - Skin ( upper part of face ) , neck , back , hands
1.1.2. Gross : - Red nodular - Ulcer ( inverted edge / fixed base / necrotic floor )
1.1.3. Microscopic : - Basaloid masses -Peripheral ballisading - Surrrounded by stroma - Melanin pigment
1.1.4. Complications : - locally invasive - 2ry infection --> lymphadenitis
2. Malignant tumors
2.1. Squamous cell carcinoma
2.1.1. Site : Stratified squamous epithelium
2.1.2. Gross : - Fungating - Ulcer ( everted edge / necrotic floor / fixed base )
2.1.3. Microscopic : - Masses of malignant stratified squamous epithelium - Variable in size , shape - Keratinized nests - separated by stroma
2.2. Carcinoma In Situ
2.2.1. Site : - Glandular , surface epithilium
2.2.2. Gross : - irregular ill defined in solid organs - Surface epithelium - ulcer - fung - Thickened
2.2.3. Microscopic : - Anaplasia - Loss of polarity - Intact BM
2.2.4. Complications : - Invasive carcinoma
2.3. Glandular carcinoma
2.3.1. Site : Glands
2.3.1.1. Adenocarcinoma
2.3.1.1.1. well differentiated ( malignant acini + stroma )
2.3.1.1.2. Poorly differentiated ( malignant cells + less acini )
2.3.1.2. Mucoid
2.3.1.2.1. Extracellular mucin lakes , malignant glands e.g : Colorectal carcinoma
2.3.1.3. Signet Ring
2.3.1.3.1. Adenocarcinoma with intracellular mucin e.g. : Gastric carcinoma , krukenberg
3. Benign tumors
3.1. Papilloma
3.1.1. Site : - Surface epithelium
3.1.2. Gross : - Papillae ( sessile / pedunclated ) - Single or Multiple branching
3.1.3. Microscopic : - Core :- Fibrous / vascular - Covered by : ( squamous - columnar - transitional ) epithelium
3.1.4. Complications : - Ulceration :- - Bleeding - 2ry bacterial infection
3.2. Adenoma
3.2.1. Site : - Glandular epithelium in ( glands - GIT )
3.2.2. Gross : - Capsulated - Well defined in solid organs - Polyp in GIT - Cystic containing secretion - Papillary cystic
3.2.3. Microscopic : - Glandular tissue - Stroma
3.2.4. Complications : - Malignant transformation - Compression / obstruction - secretion of hormones