PHYTOPHARMACEUTICALS

1. CHAMOMILE : Flowers of Matricaria recutita, Fam: Asteraceae/Compositae

1.1. Coumarin: Hernian

1.1.1. Anti-microbial and Anti-viral activity

1.2. Major-> Volatile Oils: Bisabolol, Chamazulene (formed from Matricin by Steam Distillation)

1.2.1. Bisabolol-Antiinflammatory, AntiUlcerogenic activity, Anti-spasmodic

1.2.1.1. Inhibition of Histamine release; inhibition of LOX & COX activity; Oxidation of Arachidonic acid

1.2.2. T/t of Hemarrhoids; Travel sickness ; Food flavour in Herbal teas

1.3. Minor-> Bisobolol oxide A & B, Spiroethers, Sesquiterpene:Cadinene, Farnesene, Proazulene:Mattricin : Umbelliferone; Tannins; Aminoacids:Lutein; Fatty acids

1.4. Flavanoids: Apigenin, Apiin, Quercitin.

1.4.1. Anti-inflammatory property

1.4.1.1. Inhibition of Histamine release

1.4.1.2. Inhibition of lipoxygenase and cyclooxygenase activity

1.4.1.2.1. DOSE: 2-3 gms of Dried flower heads as infusion( 3times/day) ; Alc Extract-1-4 ml (3 times/day)

1.4.2. Sedative Activity

1.4.2.1. Inhibit binding of Flunitrazepam to central BZD receptor