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NSAIDs by Mind Map: NSAIDs
5.0 stars - 1 reviews range from 0 to 5

NSAIDs

Black: non selectiveGreen: more COX-1Blue: more COX-2RED: ONYL COX-2

Salicylic acids

Aspirin

irreversible binding

do not affect NORMAL temp

GI bleeding / ulcer / asthma

metabolized to salicyluric acid

Diflunisal

4-5 times stronger analgesic than aspirin

bad antipyretic

metabolized as glucuronide

breast milk

Acetic acids

Ketorolac

good analgesic but poor anti-inflam

post operative pain

metabolized to glucuronide

Indomethacin

10-40 time stronger than aspirin

Rheumatoid arthritis

Tolmetin

rheumatoid and osteoarthritis

common side effects

food delays absorption

Sulindac

pro drug

alternative in RA

side effects

Nabumetone

NOT ACID

pro drug

less damage to stomach

Etodolac

Phenyl acetic acids

Diclofenac

stronger than aspirin as, analgesic, antipyretic, anti-inflam

2% side effects

Sulfones

Celecoxb

increased CV risks

metabolized by CYP2C9

inhibits CYP2D6

Propionic acids

Flubiprofen

ophthalmic solution

Ketoprofen

30% GI side effects

through conjugation

Fenoprofen

RA and OA

conjugation

Naproxen

more potent than aspirin

Dysmenorrhea

Ibuprofen

conjugated to form hydroxyl and carboxyl

Fenamic acids

Meclofenic acid

conjugated to hydroxy and carboxyl

20% in feces

Enolic acids

Piroxicam

hydroxylation then conjugation

Meloxicam

less GI irritation than Piroxicam

Other

Acetaminophen

not for inflammation

conjugation, glucuronides, sulfuric acid