1. Salicylic acids
1.1. Aspirin
1.1.1. irreversible binding
1.1.2. do not affect NORMAL temp
1.1.3. GI bleeding / ulcer / asthma
1.1.4. metabolized to salicyluric acid
1.2. Diflunisal
1.2.1. 4-5 times stronger analgesic than aspirin
1.2.2. bad antipyretic
1.2.3. metabolized as glucuronide
1.2.4. breast milk
2. Acetic acids
2.1. Ketorolac
2.1.1. good analgesic but poor anti-inflam
2.1.2. post operative pain
2.1.3. metabolized to glucuronide
2.2. Indomethacin
2.2.1. 10-40 time stronger than aspirin
2.2.2. Rheumatoid arthritis
2.3. Tolmetin
2.3.1. rheumatoid and osteoarthritis
2.3.2. common side effects
2.3.3. food delays absorption
2.4. Sulindac
2.4.1. pro drug
2.4.2. alternative in RA
2.4.3. side effects
2.5. Nabumetone
2.5.1. NOT ACID
2.5.2. pro drug
2.5.3. less damage to stomach
2.6. Etodolac
3. Phenyl acetic acids
3.1. Diclofenac
3.1.1. stronger than aspirin as
3.1.1.1. analgesic
3.1.1.2. antipyretic
3.1.1.3. anti-inflam
3.1.2. 2% side effects
4. Sulfones
4.1. Celecoxb
4.1.1. increased CV risks
4.1.2. metabolized by CYP2C9
4.1.3. inhibits CYP2D6
5. Propionic acids
5.1. Flubiprofen
5.1.1. ophthalmic solution
5.2. Ketoprofen
5.2.1. 30% GI side effects
5.2.2. through conjugation
5.3. Fenoprofen
5.3.1. RA and OA
5.3.2. conjugation
5.4. Naproxen
5.4.1. more potent than aspirin
5.4.2. Dysmenorrhea
5.5. Ibuprofen
5.5.1. conjugated to form hydroxyl and carboxyl
6. Fenamic acids
6.1. Meclofenic acid
6.1.1. conjugated to hydroxy and carboxyl
6.1.2. 20% in feces
7. Enolic acids
7.1. Piroxicam
7.1.1. hydroxylation then conjugation
7.2. Meloxicam
7.2.1. less GI irritation than Piroxicam
8. Other
8.1. Acetaminophen
8.1.1. not for inflammation
8.1.2. conjugation, glucuronides, sulfuric acid