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Onn Haji Hashim by Mind Map: Onn Haji Hashim
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Onn Haji Hashim

Champedak Seed Lectins & Cancer Proteomics

Publication

Book/Book Chapter

Hashim, O. (2003) Metabolisme tubuh manusia (Human body metabolism) (2nd edition), UM Press, Kuala Lumpur, 327pp (ISBN 983-100-168-0).

Hashim, O. (2000) Metabolisme tubuh manusia (Human body metabolism) (1st edition), UM Press, Kuala Lumpur, 275pp (ISBN 983-100-088-9).

Mestecky, J., Hashim, O.H. and Tomana, M. (1995) Alterations in the IgA carbohydrate chains influence the cellular distribution of IgA1. In Clarkson AR, Woodroffe AJ (eds): IgA Nephropathy: Pathogenesis and Treatment. Karger Basel., Contribution to Nephrology, 111, 66-71.

Journals

2012, Jayapalan, J. J., Ng, K. L., Razack, A. H. A. and Hashim, O. H. (2012) Identification of potential complementary serum biomarkers to differentiate prostate cancer from benign prostatic hyperplasia using gel- and lectin-based proteomics analyses. Electrophoresis, 33 (12) : 1855-1862, Chong, U. R. W., Abdul-Rahman, P. S., Abdul-Aziz, A., Hashim, O. H., Mat-Junit, S. (2012) Tamarindus indica extract alters release of alpha enolase, apolipoprotein A-I, transthyretin and Rab GDP dissociation inhibitor beta from HepG2 cells. PLoS ONE, 7(6): e39476., Chan, H. H., Rahim, Z.H.A., Jessie, K., Hashim, O.H. and Taiyeb-ali T. B. (2012) Saliva proteins associated with periodontitis in patients with Type 2 diabetes mellitus. International Journal of Molecular Sciences, 13, 4642-4654., Aminudin, N., Abdullah, N. H., Misbah, H., Karsani, S. A., Husain, R., Hoe, S. Z. and Hashim, O. H. (2012) Treatment with captopril abrogates the altered expression of alpha1 macroglobulin and alpha1 antiproteinase in sera of spontaneously hypertensive rats. Proteome Science, 10:17 (doi:10.1186/1477-5956-10-17)., Vellasamy, K.M., Mariappan, V., Hashim, O.H. and Vadivelu, J. (2012) Functions of Burkholderia virulence factors: Input from proteomics and DNA microarray analyses. Journal of Analytical Science and Technology, 3:72-80.

2011, Mariappan, V., Vellasamy, K.M., Hashim, O.H. and Vadivelu, J. (2011) Profiling of Burkholderia cepacia secretome at mid-logarithmic and early-stationary phases of growth. PLoS ONE 6(10): e26518. (doi:10.1371/journal.pone. 0026518)., Golbabapour, S., Pang, W.W., George, J., Pasupati, T., Abdul-Rahman, P.S. and Hashim, O.H. (2011) Chemically induced breast tumors in rats are detectable in early stages by contrast enhanced magnetic resonance imaging but not by changes in the acute-phase reactants in serum. International Journal of Molecular Sciences, 12, 1030-1040., Vellasamy, K.M., Mariappan, V., Hashim, O.H. and Vadivelu, J. (2011) Identification of immunoreactive secretory proteins from the stationary phase culture of Burkholderia pseudomallei. Electrophoresis, 32, 310-320., Manap, M.N.A, Hashim, O.H. and Mohd. Yusoff, K. (2011) Malaysian bee venom abrogates carrageenan induced inflammation in rats. Journal of Apiproduct and Apimedical Science, 3, 75-80.

2010, Abdullah-Soheimi, S.S., Lim, B.K., Hashim, O.H. and Shuib, A.S. (2010) Patients with ovarian carcinoma excrete different altered levels of urine CD59, kininogen-1 and fragments of inter-alpha-trypsin inhibitor heavy chain H4 and albumin. Proteome Science, 8:58 (doi:10.1186/1477-5956-8-58)., Jessie, K., Pang, W.W., Rahim, Z.H.A. and Hashim, O.H. (2010) Proteomic analysis of whole human saliva detects enhanced expression of interleukin-1 receptor antagonist, thioredoxin and lipocalin-1 in cigarette smokers compared to non-smokers, International Journal of Molecular Sciences, 11, 4488-4505., Seriramalu, R., Pang, W. W., Jayapalan, J. J., Mohamed, E., Abdul-Rahman, P. S., Bustam, A. Z., Khoo, A. S. B. and Hashim, O. H. (2010) Application of champedak mannose binding lectin in the glycoproteomic profiling of serum samples unmasks reduced expression of alpha-2 macroglobulin and complement factor B in patients with nasopharyngeal carcinoma. Electrophoresis, 31, 2388-2395., Gabrielsen, M., Abdul-Rahman, P.S., Isaacs, N.W., Hashim, O.H. and Cogdell, R.J. (2010) Crystallization and initial X-ray diffraction analysis of a mannose-binding lectin from Champedak. Acta Crystallographica F, 66, 592-594., Pang, W.W., Abdul-Rahman, P.S., Wan-Ibrahim, W.I. and Hashim, O.H. (2010) Can the acute-phase reactant proteins be used as cancer biomarkers? International Journal of Biological Markers, 25, 1-11., Mariappan, V., Vellasamy, K.M., Thimma, J.S., Hashim, O.H. and Vadivelu, J. (2010) Identification of immunogenic proteins from Burkholderia cepacia secretome using proteomic analysis. Vaccine, 28, 1318-1324.

2009, Chen, Y., Lim, B.K. and Hashim, O.H. (2009) Stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma. Journal of Hematology and Oncology, 2, 37 (doi:10.1186/ 1756-8722-2-37)., Gabrielsen, M., Riboldi-Tunicliffe, A., Abdul-Rahman, P.S., Mohamed, E., Ibrahim, W.I.W., Hashim, O.H., Isaacs, N.W. and Cogdell, R.J. (2009) Crystallization and preliminary structural studies of Champedak galactose-binding lectin, Acta Crystallographica F, 65, 895-897.

2008, Mohamed, E., Abdul-Rahman, P.S., Doustjalali, S.R., Chen, Y., Lim, B.K., Omar, S.Z., Bustam, A.Z., Singh, V.A., Muhammad-Taib, N.A., Yip, C.H. and Hashim, O.H. (2008) Lectin-based electrophoretic analysis of the expression of the 35 kDa inter-alpha-trypsin inhibitor heavy chain H4 fragment in sera of patients with five different malignancies. Electrophoresis, 29, 2645-2650., Chen, Y., Lim, B.K., Peh, S.C., Abdul-Rahman, P.S. and Hashim, O.H. (2008) Profiling of serum and tissue high abundance acute-phase proteins of patients with epithelial and germ line ovarian carcinoma. Proteome Science, 6, 20 (doi:10.1186/1477-5956-6-20)., Jessie, K., Hashim, O.H. and Rahim, Z.H.A. (2008) Precipitation methods for salivary proteins and rehydration buffer for two-dimensional electrophoresis, Biotechnology, 7(4), 686-693.

2007, Abdul-Rahman, P.S., Lim, B.K. and Hashim, O.H. (2007) Expression of high abundance proteins in sera of patients with endometrial and cervical cancers: analysis using two-dimensional gel electrophoresis with silver staining and lectin detection methods, Electrophoresis, 28, 1989-1996., Hashim, O. H. (2007) Overview of proteomics (a review), Malaysian Journal of Biochemistry and Molecular Biology, 15, 1-7.

2006, Muliawan S.Y., Lam, S.K., Devi, S., Hashim, O.H. and Yusof, R. (2006) Inhibitory potential of Quercus lusitanica extract on dengue virus type 2 replication, Southeast Asian Journal of Tropical Medicine and Public Health, 37, 132-135., Yong, P.H., Mat Junit, S., Harun, F. and Hashim, O.H. (2006) Patients with congenital hypothyroidism demonstrate different altered expression of plasma fibrinogen and haptoglobin polypeptide chains, Clinical Biochemistry, 39, 126-132., Doustjalali, S.R., Yusof, R., Govindasamy, G.K., Bustam, A.Z., Pillay, B. and Hashim, O.H. (2006) Patients with nasopharyngeal carcinoma demonstrate enhanced serum and tissue ceruloplasmin expression, Journal of Medical Investigation, 53, 20-28.

2005, Muliawan S.Y., Lam, S.K., Sidik, K., Abdul Rahman, N., Khalid, N., Hashim, O.H. and Yusof, R. (2005) Inhibitory potential of Quercus lusitanica galls extract on the protein expression of dengue virus type 2, Journal of Science and Technology in the Tropics, 1, 117-124.

2004, Doustjalali, S.R., Yusof, R., Yip, C.H., Looi, L.M., Pillay B. and Hashim, O.H. (2004) Aberrant expression of acute-phase reactant proteins in sera and breast lesions from patients with malignant and benign breast tumours, Electrophoresis, 25, 2392-2401.

2002, Abdul Rahman, M., Karsani, S.A., Othman, I., Abdul Rahman, P.S. and Hashim, O.H. (2002) Galactose binding lectin from the seeds of champedak (Artocarpus integer): sequences of its subunits and interactions with human serum O-glycosylated glycoproteins, Biochemical and Biophysical Research Communications. 295, 1007-1013.

2001, Hashim, O.H., Ahmad, F. and Shuib, A.S. (2001) The application of Artocarpus integer seed lectin-M in the detection and isolation of selective serum acute-phase proteins and immunoglobulins, Immunological Investigations, 30, 131-141., Hashim, O.H., Shuib, A.S. and Chua, C.T. (2001) Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains, Nephron, 89, 422-425., Hashim, O.H., Shuib, A.S. and Chua, C.T. (2001) The interaction of selective plant lectins with neuraminidase-treated and untreated IgA1 from the sera of IgA nephropathy patients, Immunological Investigations, 30, 21-31., Hashim, O.H. and Shuib, A.S. (2001) Champedak and jackfruit galactose-reactive lectins demonstrated minor preferential binding to electrophoresed alpha-heavy chains lacking in sialic acid residues, Malaysian Journal for Biochemistry and Molecular Biology, 6, 40-43.

1998, Lim, S.B., Kanthimathi, M.S. and Hashim, O.H. (1998) Effect of the mannose-binding Artocarpus integer lectin on the cellular proliferaton of murine lymphocytes. Immunological Investigations, 27, 395-404., Shuib, A.S., Chua, C.T. and Hashim, O.H. (1998) Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha heavy chains. Nephron, 78, 290-295.

1997, Lim, S.B., Chua, C.T. and Hashim, O.H. (1997) Isolation of a mannose-binding and IgE- and IgM-reactive lectin from the seeds of Artocarpus integer. Journal of Immunological Methods, 209, 177-186.

1994, Hashim, O.H., Gendeh, G.S., Cheong, C.N. and Nik Jaafar, M.I. (1994) Effect of Artocarpus integer lectin on functional activity of guinea-pig complement. Immunological Investigations, 23, 153-160., Hashim, O.H. and Adnan, N.A. (1994) Coenzyme, cofactor and prosthetic group - ambiguous biochemical jargon. Biochemical Education, 22, 93-94., Hashim, O.H. and Chong, H.A.A.H. (1994) Detection of mannose-binding lectins in crude extracts of champedak and jackfruit seeds, Proc. Mal. Biochem. Mol. Biol. Soc. Conf., 19, 230-233.

1993, Hashim, O.H., Gendeh, G.S. and Nik Jaafar, M.I. (1993) Comparative analyses of IgA1 binding lectins from seeds of six distinct clones of Artocarpus integer. Biochemistry and Molecular Biology International, 29, 69-76.

1992, Hashim, O.H., Gendeh, G.S. and Nik Jaafar, M.I. (1992) Lectin extracts of champedak seeds demonstrate selective stimulation of T lymphocyte proliferation. Biochemistry International, 27, 139-143., Hashim, O.H., Kobayashi, K. and Taniguchi, N. (1992) Interaction of Artocarpus lectins with human IgA does not involve asparagine-linked oligosaccharide of the immunoglobulin. Biochemistry International, 27, 423-429., Hashim, O.H. and Rahim, Z.H.A. (1992) Quantitative estimation of IgA1 using Artocarpus integer lectin - a preliminary investigation. Proc. Mal. Biochem. Soc. Conf., 17, 188-191.

1991, Hashim, O.H., Ng, C.L., Gendeh, G.S. and Nik Jaafar, M.I. (1991) IgA binding lectins from distinct Artocarpus species demonstrate differential specificity. Molecular Immunology, 28, 393-398., Hashim, O.H. (1991) The ELISA test (a videotape review). Biochemical Education, 19, 38., Hashim, O.H. and Hassan, H. (1991) Actions of three Clostridial IgA proteases on distinct forms of immunoglobulin A molecules. Immunology, 73, 235-238., Hashim, O.H., Devadason, V. and Hassan, H. (1991) Kinetics of IgA1 protease activity from broth culture supernatant of Clostridium septicum. Proc. Mal. Biochem. Soc. Conf. 16, 100-103.

1990, Rahim, Z.H.A. and Hashim, O.H. (1990) Effect of molecular size of IgA on its quantitative assay by immunonephelometry. Proc. Mal. Biochem. Soc. Conf. 15, 162-163, Hashim, O.H., Ng, C.L. and Nik Jaafar, M.I. (1990) Jacalin-IgA interaction: existence of two binding sites? Proc. Mal. Biochem. Soc. Conf. 15, 164-165.

1989, Hashim, O.H. and Nik Jaafar, M.I. (1989) IgA binding lectin from jackfruit seeds. Proc. Mal. Biochem. Soc. Conf. 14, 210-212., Hashim, O.H. and Cushley, W. (1989) Affinity interaction of N-linked oligosaccharide structures of IgG2b with Concanavalin A. Proc. Mal. Biochem. Soc. Conf. 14, 217-219.

1988, Hashim, O.H. and Cushley, W. (1988) Simultaneous inhibition of multiple steps in the processing of N-linked oligosaccharides does not impair immunoglobulin secretion from rat hybridoma cells. Immunology, 63, 383-388., Hashim, O.H. and Cushley, W. (1988) Inhibition of N-linked oligosaccharide processing of IgG leads to potentiated complement fixation. Proc. Fed. Asian Oceanian Biochem. Symp. 7, 95-96.

1987, Hashim, O.H. and Cushley, W. (1987) Minor modifications to the structure of Tunicamycin lead to loss of the biological activity of the antibiotic. Biochimica et Biophysica Acta, 923, 362-370., Hashim, O.H. and Cushley, W. (1987) Role of processing of N-linked oligosaccharides in control of immunoglobulin secretion from rat hybridomas. Molecular Immunology, 24, 1087-1096.

General

Current Positon

Head, Department of Molecular Medicine, Faculty of Medicine, University of Malaya

Head, University of Malaya Centre for Proteomics Research (UMCPR)

Working Experience

Member, Advisory Board, Health and Translational Medicine (HTM) Cluster, University of Malaya

Panel Member, Advanced Fundamental Research Cluster – appointed by the Deputy Vice-Chancellor, Research & Innovation

Panel Member, Biotechnology and Bioinnovation Research Cluster

Member, University of Malaya Postgraduate Supervision Committee

Member, Selection Committee of Post-Doctoral Research Fellow, University of Malaya

Member, Short-term Research Funding (PJP) Committee (Research University Special Grant 2008), University of Malaya

Chairman, Post-Graduate Committee to Conduct Examiners’ Meeting for a PhD Programme

Proteomics Advisor, Medical Biotechnology Laboratory – appointed by the Dean, Faculty of Medicine, University of Malaya

Chairman, Ad-Hoc Committees to evaluate applications for PhD candidature – appointed by the Faculty Board

Medical Biochemistry Programme Coordinator for the MBBS course

Pharmaceutical Biochemistry Programme Coordinator for the BPharm course

Professional Membership

Panel Member, Health and Translational Medicine (HTM) Cluster

Panel Member, Advanced Fundamental Research Cluster

Panel Member, Biotechnology and Bioinnovation Research Cluster

Member, Editorial Board, Journal of the University of Malaya Medical Centre (JUMMEC)

Member, Faculty of Medicine Conference Committee, University of Malaya

Member, Panel for Renewal of Contract for Research Officer, University of Malaya

Panel Chairman for Appointment of Research Officers, University of Malaya

Research Profile

Um Expert

Researcher ID

Scopus

PubMed

UM Repository

Google Scholar

Microsoft Academic Search

ResearchGate

Academia.edu

Selected.Work

CiteULike

Wizfolio

Publication.List

Mendeley

Award & Prizes

Gold medalist, Innovation & Creativity / Research & Innovation Expositions, University of Malaya. 2010 & 2004

Recipient of the National Academic Award 2007 – Category of Journal Article Publication. 2008

Recipient of the Excellence in Service Awards for Years 2007, 2004 and 2000, University of Malaya. 2008, 2005 & 2001

Recipient of the Excellence in Service Certificate for Years 2006 and 2005, University of Malaya. 2007 & 2006

Recipient of the Excellent Scientist Certificate of Appreciation, Ministry of Higher Education. 2005

Gold medalist, 33rd International Exhibition of Inventions, New Techniques and Products, Geneva, Switzerland. 2005

Silver medalist, National Science, Technology and Innovation Exposition. 2004

Recipient of the Certificate of Merit for Best Presentation, (Session on Biochemistry and Pharmacology) at the Health Sector Review Conference, University of Malaya Medical Centre. 1999

Recipient of the Best MBBS Stage I Lecturer Award (voted by the 1996/97 batch of medical students). 1997

Recipient of the Fulbright Scholar Award (USA). 1993

Recipient of the Japan Society for the Promotion of Science (JSPS) Research Fellowship. 1991

Patents

Hashim, O.H. and Shuib, A.S. (2004) Lectin-based pregnancy test kit (method for detecting hCG hormone and test kit thereof) – PI20041268. This invention was exhibited at more than ten different local and international expositions

Hashim, O.H., Abdul-Rahman P.S. and Doust-Jalali, S.R. (2008) A method for detecting the 35 kDa O-glycosylated inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) fragments (application in cancer diagnosis) – PI20084944.

Others

External Appoinments

Expert Panel for Evaluation of Funding for Research, Development and Commercialisation, appointed by the Ministry of Science, Technology and Innovation, Malaysia (2010 – 2012).

Panel member (Medical biochemistry) for accreditation, Malaysian Qualifications Agency (2009 – 2012).

External Examiner of the Biochemistry programmes of the MBBS Course

External Examiner of the Biochemistry programmes of the BDS Course

Member, Editorial Board of the Malaysian Journal of Biochemistry and Molecular Biology (2010 – 2012).

Member, National Academic Award Selection Committees – appointed by the Ministry of Higher Education Malaysia (2009, 2010, 2011 & 2012).

Auditor, Malaysian Society for Biochemistry and Molecular Biology (2010 – 2011).

Academic Advisor to the School of Biosciences & Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (2009).

Academic Advisor to the School of Biosciences & Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (2009).

Member, National Strategic Sector Advisory Committee (Biotechnology) – appointed by the Ministry of Higher Education Malaysia (2007 – 2009).

Editor-in-Chief of the Malaysian Journal of Biochemistry and Molecular Biology (2006 – 2009).

New node

External Examiners

PhD, MSc and/or MMedSc theses

Universiti Kebangsaan Malaysia

Universiti Putra Malaysia

Universiti Sains Malaysia

Universiti Islam Antarabangsa Malaysia

International Medical University

National University of Singapore

Reviewer of scientific manuscripts

Reviewer of scientific manuscripts for peer-reviewed international journals

Electrophoresis

International Journal of Cancer

Journal of Hematology and Oncology

Proteomics

PLoS One

Cancer Cell International

Bioorganic & Medicinal Chemistry Letters

External Assessor

External Assessor for the promotion/intake exercise of Professors, Associate Professors and/or Academic Staff for

Universiti Kebangsaan Malaysia

Universiti Putra Malaysia

Universiti Sains Malaysia

Universiti Islam Antarabangsa Malaysia

International Medical University

Monash University Sunway Campus