6. Leukemia-predisposing conditions

Get Started. It's Free
or sign up with your email address
6. Leukemia-predisposing conditions by Mind Map: 6. Leukemia-predisposing conditions

1. Leukemia

1.1. accounts for 30%~ Paeds cancer

1.2. most sporadic

2. PAX5

2.1. AD, reduced penetrance

2.2. B-ALL in childhood

2.3. no screen recommendation

3. CEBPA

3.1. AD

3.2. AML

4. LFS

4.1. low hypodiploid B-ALL

5. ETV6

5.1. B-ALL (MDS, AML, MM)

6. GATA2

6.1. AD

6.2. symptoms

6.2.1. MDS -> AML

6.2.1.1. MDS: myelodysplasia - bone marrow cells do not develop into mature blood cells

6.2.1.1.1. (so has to develop into AML)

6.3. co-morbidity

6.3.1. HPV and Epstein-Barr virus infection

7. Mnemonic

7.1. Pc LEg

7.1.1. Always Sitting in front of PC, LEg has no muscle; Exposed to radiation, got Leukemia

7.1.2. P,L,E: ALL

7.1.3. c, g: AML

8. Surveillance

8.1. refer to specialist

8.2. educate on signs of leukemia

8.2.1. cheek "rash"

8.2.2. fatigue, fever, brusing, spenomegaly

8.3. think about transplant

9. Surveillance testing

9.1. CBC

9.2. bone marrow aspiration and biopsy

10. What is the difference between AML and ALL?

10.1. AML and ALL are the two main types of acute leukaemia. The difference between them is the type of white blood cell affected.

11. Leukemia-predisposing conditions

11.1. Single genes

11.1.1. PAX5

11.1.2. CEBPA

11.1.3. ETV6

11.1.4. GATA2

11.2. Cancer syndrome

11.2.1. LFS

11.2.1.1. low hypodiploid B-ALL

11.2.2. CMMRD

11.2.2.1. ALL & AML

11.3. chr instability syndromes

11.3.1. FA

11.3.2. Nijmegen

11.3.3. AT

11.3.4. Bloom

11.3.5. DKC

11.3.6. Shwachman-Diamond

11.3.7. Diamond-Blackfan syndrome

11.4. RAS-opathies

11.4.1. NF1

11.4.2. Noonan

11.5. Aneuploidy

11.5.1. T21

11.5.1.1. acute megakaryocytic leukemia