willaime et.al. Texture features and proliferation

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willaime et.al. Texture features and proliferation by Mind Map: willaime et.al. Texture features and proliferation

1. FLT-PET

1.1. uptake is correlated with cell proliferation Ki-67 labeling index

2. 28 descriptors

3. heterogeneity > tumor growth and treatment failure

4. Initially 15 Patients

4.1. histologically proven breast cancer

4.2. at least one lesion with minimum diameter 2.5 cm

4.3. was staged at II and IV according AJCC

4.4. had not received any treatment

4.5. Only 12 were in analysis

5. PET Scan

5.1. ECAT 962/HR+ Siemens

5.2. Time = 95 min

5.3. Dynamic PET, planed dose 370 MBq

5.4. 31 discrete frames

5.5. OSEM reconstruction 360 iter, 6 subsets

5.6. FWHM 5.0 mm

5.7. voxel reconstructed size 2.651x2.651x2.420

5.8. ROI and VOI - manual

6. GLCM

6.1. computed on dynamic PET images averaged over 32-45 min

6.2. GCLM - 13 orientations 2 directions , distance - one , 26 neighbors. Texture from all GLCM were averaged over 13 directions

7. GLSZM grey-level size-zone matrix, 13 total

7.1. Cupture information about the size and intensities of the clusters of voxels

8. NGTDM, 4 total

8.1. local intensities differences between each voxel and its 26 neighbors

9. SUV, mean and max over 60 minutes

10. FOS, first order statistics

11. Analysis

11.1. Repeatability: ability of the features to give consistent results for the same subject scanned twice without an intervening treatment

11.1.1. Only features with high repeatability, ICC >=0.7

11.1.2. 5 cases , Shapiro-Wilk test

11.1.3. Very High repeatability

11.1.3.1. Coefficient of Variability

11.1.3.2. InfCo2

11.1.3.3. Contrast from GLCM

11.1.3.4. dissimilarity

11.1.3.5. complexity

12. Response after 60 days