willaime et.al. Texture features and proliferation

1. GLSZM grey-level size-zone matrix, 13 total

1.1. Cupture information about the size and intensities of the clusters of voxels

2. NGTDM, 4 total

2.1. local intensities differences between each voxel and its 26 neighbors

3. SUV, mean and max over 60 minutes

4. FOS, first order statistics

5. Analysis

5.1. Repeatability: ability of the features to give consistent results for the same subject scanned twice without an intervening treatment

5.1.1. Only features with high repeatability, ICC >=0.7

5.1.2. 5 cases , Shapiro-Wilk test

5.1.3. Very High repeatability

5.1.3.1. Coefficient of Variability

5.1.3.2. InfCo2

5.1.3.3. Contrast from GLCM

5.1.3.4. dissimilarity

5.1.3.5. complexity

6. Response after 60 days

7. FLT-PET

7.1. uptake is correlated with cell proliferation Ki-67 labeling index

8. 28 descriptors

9. heterogeneity > tumor growth and treatment failure

10. Initially 15 Patients

10.1. histologically proven breast cancer

10.2. at least one lesion with minimum diameter 2.5 cm

10.3. was staged at II and IV according AJCC

10.4. had not received any treatment

10.5. Only 12 were in analysis

11. PET Scan

11.1. ECAT 962/HR+ Siemens

11.2. Time = 95 min

11.3. Dynamic PET, planed dose 370 MBq

11.4. 31 discrete frames

11.5. OSEM reconstruction 360 iter, 6 subsets

11.6. FWHM 5.0 mm

11.7. voxel reconstructed size 2.651x2.651x2.420

11.8. ROI and VOI - manual

12. GLCM

12.1. computed on dynamic PET images averaged over 32-45 min

12.2. GCLM - 13 orientations 2 directions , distance - one , 26 neighbors. Texture from all GLCM were averaged over 13 directions