Biosurveillance and Pathogen Early-Warning in the U.S. Federal Government *Last update: November ...
1. State Department
1.1. Bureau of Arms Control, Deterrence, and Stability
1.1.1. Office of Chemical and Biological Weapons Affairs
1.2. Bureau of Intelligence and Research (INR)
1.3. Office of the Science and Technology Adviser
1.4. Bureau of Global Health Security and Diplomacy
1.5. Regional Bureaus
1.6. Bureau of International Security and Nonproliferation
1.6.1. Office of Cooperative Threat Reduction
1.6.2. Office of The Biological Policy Staff
1.6.3. Office of Weapons of Mass Destruction Terrorism
1.7. Bureau of Oceans and International Environmental and Scientific Affairs
1.7.1. Office of Environmental Quality
1.7.2. Office of Science and Technology Cooperation
2. Intelligence Community
2.1. FBI
2.2. Office of the Director of National Intelligence
2.2.1. IARPA
2.2.1.1. Finding engineering-linked indicators (FELIX) program
2.2.2. National Counterproliferation and Biosecurity Center
2.3. Defense Intelligence Agency
2.3.1. National Center for Medical Intelligence (NCMI)
2.4. CIA
3. Department of Homeland Security
3.1. Countering Weapons of Mass Destruction Office (CWMD)
3.1.1. National Biosurveillance Integration Center (NBIC)
3.1.2. BioWatch
3.1.3. Biological Detection for the 21st Century
3.1.4. Strategy for Integrated Biosurveillance
3.2. U.S. Customs and Border Protection
3.2.1. National Targeting Center
3.3. Science and Technology Directorate (S&T)
3.3.1. National Laboratories
3.3.1.1. National Biodefense Analysis and Countermeasures Center
3.3.1.1.1. National Biological Threat Characterization Center
3.3.1.1.2. National Bioforensic Analysis Center
3.3.1.2. Plum Island Animal Disease Center
3.3.2. Chemical, Biological and Explosive Defense R&D
3.3.2.1. Chemical and Biological Detection Program
3.3.3. Probabilistic Analysis for National Threats Hazards and Risks (PANTHR)
3.4. Federal Emergency Management Agency (FEMA)
3.4.1. Biological Incident Annex
4. Department of the Interior
4.1. U.S. Geological Survey
4.1.1. National Wildlife Health Center
4.1.1.1. WHISPers, the Wildlife Health Information Sharing Partnership - event reporting system
4.1.2. Disease Decision Analysis and Research
4.2. National Invasive Species Council
4.2.1. Early Detection and Rapid Response
5. Department of Commerce
5.1. National Institute of Standards and Technology (NIST)
5.1.1. Wastewater Surveillance
5.1.2. Standards to Support Biothreat Detection
5.1.3. Pathogen Detection and Identification in the Clinical Setting: The Next Generation of Analyses
5.1.4. Standards for Assessing the Safety of Recreational Waters from Fecal Contamination
5.1.5. Measuring Antimicrobial Resistance
5.1.6. Mpox (MPXV) Synthetic DNA PCR Standards
5.2. Bureau of Industry and Security
6. Department of Labor
6.1. OSHA
7. Department of Defense
7.1. Chemical and Biological Defense Program (CBDP): Project overview
7.1.1. Understand Portfolio (selected efforts, more at the link)
7.1.1.1. UN2 / Applied Research and UN3 / Advanced Technology Development
7.1.1.1.1. CBRN Situational Awareness
7.1.1.1.2. CBRN Situational Awareness - Enhanced Biodefense
7.1.1.1.3. Distributed CB Reconnaissance
7.1.1.1.4. Enhanced and Emerging Biothreat Sensing
7.1.1.1.5. Unattended Perimeter Monitoring - Biological Detection
7.1.1.2. UN4 / Advanced Component Development & Prototypes
7.1.1.2.1. Advanced Emerging Threat Defense
7.1.1.2.2. CBRN Support to Command and ControL
7.1.1.2.3. Non-Targeted Sequencing Identification System
7.1.1.2.4. Physiological Monitoring Sensor Suite
7.1.1.3. UN5 / System Development & Demonstration
7.1.1.3.1. Chemical and Biological Wearables - Enhanced Biodefense
7.1.1.3.2. Far Forward Biological Sequencing
7.1.1.3.3. Joint Biological Tactical Detection System
7.1.1.3.4. Mobile Field Kit
7.1.1.3.5. Nuclear Biological Chemical Reconnaissance Vehicle Sensor Suite Upgrade
7.1.1.3.6. NGDS 2 Man Portable Diagnostic System
7.1.1.3.7. Wearable All Hazard Report Monitoring Program
7.1.2. Common Analytical Laboratory System
7.2. Offices and agencies involved
7.2.1. Office of the Secretary of Defense
7.2.1.1. Under Secretary of Defense for Acquisition and Sustainment
7.2.1.1.1. Office of the Assistant Secretary of Defense for Nuclear, Chemical, and Biological Defense Programs
7.2.1.2. Under Secretary of Defense for Intelligence and Security
7.2.1.2.1. Defense Intelligence Agency
7.2.1.3. Under Secretary of Defense for Personnel and Readiness
7.2.1.3.1. Health Affairs
7.2.1.4. Under Secretary of Defense for Research & Engineering
7.2.1.4.1. DARPA
7.2.1.4.2. Defense Science Board
7.2.1.4.3. Defense Innovation Board
7.2.1.4.4. University Affiliated Research Centers (UARC)
7.2.1.5. 2023 Biodefense Posture Review
7.2.1.5.1. Chapter IV: Enhancing Early Warning and Understanding to Counter Biothreats
7.2.1.6. Office of Net Asessment
7.2.2. Joint Chiefs of Staff and Services
7.2.2.1. Department of the Army
7.2.2.1.1. U.S. Army Combat Capabilities Development Command
7.2.2.1.2. U.S. Army Medical Research & Development Command
7.2.2.1.3. JPEO-CBRND Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense
7.2.2.2. Department of the Navy
7.2.2.2.1. Naval Medical Research Command
7.2.2.2.2. Office of Naval Research
7.2.2.3. Department of the Air Force
7.2.2.3.1. Air Force Research Laboratory
7.2.3. Defense Innovation Unit
7.2.3.1. Wastewater/ANTI-DOTE
7.2.4. Federally Funded Research and Development Centers
7.2.4.1. Massachusetts Institute of Technology- Lincoln Laboratory
8. U.S. Fish and Wildlife Service
8.1. Zoonotic Disease Initiative
8.2. Law Enforcement Management Information System (LEMIS)
9. Color code key
9.1. Policy & Coordination
9.2. Data aggregation
9.3. Implementation & Operation
9.4. Research, Technology & Innovation
9.5. Regulation
9.6. Lab-based efforts & Forensics
9.7. Other
10. HHS Office of the Secretary
10.1. Administration for Strategic Preparedness and Response (ASPR)
10.1.1. Strategic National Stockpile
10.1.2. Biomedical Advanced Research and Development Authority (BARDA)
10.1.2.1. Detection, Diagnostics, and Devices Infrastructure (DDDI) Medical Countermeasures Program
10.1.2.2. BARDA DRIVe
10.1.2.2.1. Agnostic Diagnostics
10.1.2.2.2. ENACT
10.1.2.2.3. COVID-19 At-Home Diagnostic
10.1.2.2.4. Host-based diagnostics
10.1.2.2.5. Lab at home
10.1.3. Office of Preparedness
10.1.4. HHS Coordination Operations and Response Element (H-CORE)
10.2. National Health Security Strategy
10.3. Office of Global Affairs (OGA)
10.3.1. Office of Pandemics and Emerging Threats
10.4. Assistant Secretary for Planning and Evaluation
10.5. Office of the Assistant Secretary for Health
10.5.1. Office of Infectious Disease and HIV/AIDS Policy
10.5.2. U.S. Public Health Service
10.5.3. Office of the Surgeon General
10.6. Advanced Research Projects Agency for Health (ARPA-H)
10.6.1. BREATHE Program
11. Environmental Protection Agency
11.1. ExpoBox
11.2. Safe and Sustainable Water Resources Research Program
12. White House
12.1. National Biodefense Strategy
12.1.1. Goal 1: Enable Risk Awareness and Detection to Inform Decision-Making across the Biodefense Enterprise
12.2. National Security Strategy
12.3. American Pandemic Preparedness Plan
12.3.1. Goal 4: Early-Warning Systems
12.3.2. Goal 5: Real-time Monitoring
12.4. Office of Science and Technology Policy
12.5. Office of Pandemic Preparedness and Response Policy
12.6. National Security Council
13. Centers for Medicare & Medicaid Services
14. National Institutes of Health
14.1. National Institute of Allergy and Infectious Diseases
14.1.1. Priority and Prototype Pathogen Research
14.2. Office of Science Policy
14.3. Fogarty International Center
14.4. National Science Advisory Board for Biosecurity (NSABB)
14.5. Rapid Acceleration of Diagnostics (RADx)
14.6. National Center for Biotechnology Information
15. Food and Drug Administration
15.1. Office of Counterterrorism and Emerging Threats
15.2. Center for Biologics Evaluation and Research
15.3. Office of Regulatory Affairs
15.4. Microbiology Research (Food)
15.4.1. Whole Genome Sequencing (WGS) Program
15.4.1.1. GenomeTrakr Network
15.5. Medical Devices
15.5.1. Database for Reference Grade Microbial Sequences (FDA-ARGOS)
16. Centers for Disease Control and Prevention
16.1. Many CDC surveillance efforts are collaborative efforts with state, local, and territorial partners.
16.2. Office of Readiness and Response
16.2.1. Center for Forecasting and Outbreak Analytics
16.2.1.1. Insight Net: National Outbreak Analytics & Disease Modeling Network
16.2.2. Emergency Operations Center
16.2.3. Public Health Emergency Preparedness: State and Local Readiness
16.3. Office of Public Health Data, Surveillance, and Technology
16.3.1. Public Health Data Strategy
16.4. Epidemic Intelligence Service
16.5. Global Health Center
16.5.1. Division of Global Health Protection
16.5.1.1. Global Disease Detection Operations Center
16.5.1.1.1. Event-based surveillance
16.5.1.2. Integrated Disease Surveillance & Response
16.5.2. Division of Global HIV & TB
16.5.3. Division of Parasitic Diseases and Malaria
16.6. National Center for Emerging and Zoonotic Infectious Diseases
16.6.1. Division of Infectious Disease Readiness & Innovation
16.6.1.1. Laboratory Response Network for Biological Threats
16.6.1.1.1. National Laboratories
16.6.1.1.2. Reference Laboratories
16.6.1.1.3. Sentinel Laboratories
16.6.1.2. Advanced Molecular Detection Program
16.6.1.3. National Wastewater Surveillance System (NWSS)
16.6.1.3.1. DCIPHER platform
16.6.1.4. Emerging Infections Program
16.6.1.4.1. Healthcare-associated infections
16.6.1.5. Epidemiology and Laboratory Capacity for Prevention and Control of Emerging Infectious Diseases
16.6.2. Division of Global Migration Health
16.6.2.1. Travelers' Health
16.6.2.1.1. Traveler-based Genomic Surveillance program (TGS)
16.6.3. Response Ready Enterprise Data Integration platform (Formerly: HHS Protect)
16.6.4. Division of Foodborne, Waterborne, and Environmental Diseases
16.6.4.1. Foodborne Disease Surveillance
16.6.4.1.1. FoodNet
16.6.4.1.2. Foodborne Disease Outbreak Surveillance System
16.6.4.1.3. National Antimicrobial Resistance Monitoring System for Enteric Bacteria
16.6.4.1.4. National Surveillance of Bacterial Foodborne Illnesses
16.6.4.1.5. CaliciNet
16.6.4.1.6. PulseNet
16.6.4.1.7. System for Enteric Disease Response, Investigation, and Coordination (SEDRIC)
16.6.4.2. Animal Contact Outbreak Surveillance System
16.6.4.3. Waterborne Disease Surveillance
16.6.4.3.1. Waterborne Disease & Outbreak Surveillance Reporting
16.6.4.3.2. CryptoNet
16.6.4.3.3. One Health Harmful Algal Bloom System
16.7. National Center for Environmental Health
16.7.1. National Environmental Assessment Reporting System
16.8. National Center for Immunization and Respiratory Diseases (NCIRD)
16.8.1. Viral Surveillance
16.8.1.1. Respiratory Virus Hospitalization Surveillance Network (RESP-NET)
16.8.1.1.1. COVID-NET
16.8.1.1.2. RSV-NET
16.8.1.1.3. FluSurv-NET
16.8.1.2. Respiratory Virus Laboratory Emergency Department Network Surveillance (RESP-LENS)
16.8.1.3. National Respiratory and Enteric Virus Surveillance System
16.8.1.4. National Enterovirus Surveillance System
16.8.1.5. Influenza surveillance
16.8.1.5.1. FluView
16.8.1.5.2. World Health Organization (WHO) Collaborating Center for Surveillance, Epidemiology and Control of Influenza
16.8.1.6. National SARS-CoV-2 genomic surveillance and nowcasting
16.8.2. Bacterial surveillance
16.8.2.1. Active Bacterial Core Surveillance
16.8.3. National Outbreak Reporting System
16.9. National Center for HIV, Viral Hepatitis, STD, and TB Prevention
16.10. Federal Select Agent Program
16.11. National Syndromic Surveillance Program
16.11.1. Electronic Surveillance System for the Early Notification of Community-Based Epidemics (ESSENCE)
16.12. Health Alert Network
16.13. Centers of Excellence: Collaboration between U.S. agencies and academic institutions
16.13.1. Pathogen Genomics Centers of Excellence
16.13.2. National Wastewater Surveillance System’s Centers of Excellence
16.14. National Notifiable Diseases Surveillance System
16.15. Increasing Community Access to Testing (ICATT)
17. Department of Veterans Affairs
18. National Science Foundation
18.1. The National Ecological Observatory Network
18.1.1. Pathogen testing
19. National Interagency Biodefense Campus (NIBC)
19.1. National Interagency Confederation for Biological Research
20. Postal Service
20.1. Biohazard Detection System
21. U.S. Agency for International Development
21.1. Global Health
21.1.1. Infectious Disease Detection and Surveillance
21.2. Agriculture and Food Security
21.3. STOP Spillover
22. Department of Energy
22.1. National Laboratories
22.1.1. National Virtual Biotechnology Laboratory
22.2. National Nuclear Security Administration
22.2.1. Bioassurance Program
23. Department of Agriculture
23.1. National Institute of Food and Agriculture
23.1.1. Agricultural Biosecurity Programs
23.1.1.1. National Plant Diagnostic Network
23.1.1.2. National Animal Health Laboratory Network