Anti-epileptic Drugs

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Anti-epileptic Drugs by Mind Map: Anti-epileptic Drugs

1. Sodium Channel

1.1. PHT

1.1.1. Major 1st line

1.1.2. Only one IV??

1.1.3. ADE

1.1.3.1. Gingival hyperplasia

1.1.3.2. Osteoporosis

1.1.3.3. Vit. K deficiency

1.1.3.4. Purple glove syndrome

1.1.3.5. Acne

1.1.4. First Order Kinetics

1.1.5. All types except...

1.1.5.1. Absence

1.1.5.2. Myoclonic

1.2. Carbamezapine

1.2.1. Auto-induction for metabolism

1.2.2. ADE

1.2.2.1. Diplopia

1.2.2.2. Headache

1.2.2.3. Dizziness

1.2.2.4. SJS

1.2.2.5. Aplastic Anemia

1.2.3. Szr Types

1.2.3.1. GCT

1.2.3.2. Partial

1.3. Oxcarbazepine

1.3.1. Similar MOA to CBZ

1.3.2. Lesser side effects

1.4. Fosphenytoin

1.4.1. Same as PHT

1.4.2. Better, due to lack of ADE

1.4.3. COST

1.5. Lamotrigine

1.5.1. Auto-induction on high doses

1.5.2. ADE

1.5.2.1. Rash

1.5.2.2. SJS

1.5.2.3. TEN

1.5.3. Excellent Safety Profile

1.5.3.1. Work for Elderly & Pregnant ladies

1.6. Zonisamide

1.6.1. Partial szr

1.6.2. ADE

1.6.2.1. SJS

1.6.2.2. TEN

1.6.2.3. Renal Stones

1.7. Topiramte

1.7.1. Renal stone

1.7.2. Migraine

1.7.3. Lower weight

2. Calcium Channel

2.1. VPA

2.1.1. All types of seizures

2.1.2. ADE

2.1.2.1. PCOS in young ladies

2.1.2.2. NTDs

2.2. Ethosuximide

2.2.1. Only with Absence szr

2.2.2. ADE

2.2.2.1. CNS

2.2.2.2. GI

3. GABA Enhancers

3.1. Vigabatrin

3.1.1. Refractoy epilepsy

3.1.2. Not GTC szr

3.1.3. Worsen

3.1.3.1. Myoclonic

3.1.3.2. Absence

3.1.4. ADE

3.1.4.1. Loss of peripheral vision

3.2. Gabapentin

3.2.1. Theoretically works

3.2.2. Preferred in patients with hepatic diseases

3.2.3. Sedation in elderly

3.3. Phenobarbital

3.3.1. Status epilepticus

3.3.2. Prepare patient for intubation

3.4. Primidone

4. Glutamate Blockers

4.1. Felbamate

4.2. 2nd line for Lennox szr

4.3. ADE

4.3.1. Liver failure

4.3.2. Aplastic anemia

5. Carbonic Anhydrase Inhibitors

6. SEX Hormones

6.1. Progestrone is AED

6.2. Estrogen is proconvulsants

7. Leviteracetam

7.1. Hallucination in kids

7.2. MOA unknown