1. bacitracin
1.1. Highly toxic
1.2. Used toplically
1.3. Could be combined with hydrocortisone and poymixin B in treatment of skin scars or infections
2. Cycloserine
2.1. BBB
2.2. Tb treatment
2.3. Analog to D alanine
2.4. Taken orally
2.5. Cause CNS dysfunction
3. Beta lactams
3.1. Penicillins
3.1.1. Natural
3.1.1.1. Penicillin G (injection)
3.1.1.2. Penicillin V (oral)
3.1.2. Semi-synthetic
3.1.2.1. Beta lactamase resistant
3.1.2.1.1. Methicillin - nafcillin- oxacillin
3.1.2.2. Extended release
3.1.2.2.1. Amino penicillins
3.1.2.3. Anti pseudomonas
3.1.2.3.1. Ureidopenicillins
3.1.2.3.2. Carboxypenicillins
3.2. Cephalosporins
3.2.1. 1st gen
3.2.1.1. Cephalexin - cafadroxil - cefazolin- caphradine
3.2.1.2. G +ve
3.2.2. 2nd gen
3.2.2.1. Cefaclor -cefprozil - cefuroxime
3.2.2.2. Less activity against G+ve
3.2.3. 3rd gen
3.2.3.1. Cefixime - cefbutene - ceftrixone
3.2.3.2. Caftazide is the only one in 3rd gen active against pseudomonas infections
3.2.4. 4th gen
3.2.4.1. Cefepime
3.2.4.2. G+ve & G-ve
3.2.4.3. Iv or Im
3.2.5. 5th gen
3.2.5.1. Ceftaroline - cefbiprole
3.2.5.2. Active against MRSA
3.2.5.3. NOT active against pseudomonas
3.2.5.4. G-ve
3.3. Monobactams
3.3.1. Aztreonam
3.3.2. G-ve bacteria only
3.3.3. No cross allergy
3.3.4. Lacks bicyclic nucleus
3.4. Carbapenems
3.4.1. Imepenem - meropenem
3.4.1.1. Penetrating BBB and CNS
3.4.1.1.1. Ttt of meningitis
3.4.1.2. Imipenem not used now as it causes seizures
3.4.1.3. Meropenem active against G-ve bacillary meningitis
3.4.2. Thienamycin is the first carbapenem discovered
3.4.3. Active againist all types of bacteria
3.4.4. Brodest spectrum antibiotic
3.4.5. Synergistic effect with aminoglycosides