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TEDxAmsterdam 2013 Stem cells: Dr Jekyll or Mr Hyde? by Mind Map: TEDxAmsterdam 2013
Stem cells: Dr Jekyll or Mr
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TEDxAmsterdam 2013 Stem cells: Dr Jekyll or Mr Hyde?


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Hans Clevers, Interview with Frenk van der Linden @ TEDxAmsterdam

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Themes, Biology, Future of medicine

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Reactions, "A month ago I thought PowerPoint was a tool for sharpening pencils" #tedxams Hans Clevers quoting Charles Leblond., Hans Clevers bij #TEDxAms over stamcellen. Maybe this is why your gut feeling is so strong? ;-) [pic] —, Hans Clevers: “Ideas will evoke an avalanche of interconnected consequences” #TEDxAms …, @TEDxAms Great talk by Hans Clevers. Dawn of the medical revolution. Thanks Hans!! #TEDxAms @_knaw @niooknaw

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Think about our body

conistst of organs

for example, the liver

organs conist of tissues

tissues consiists of cells

the working blocks of our body

not an easy life, they work hard, they get diseases

the problems that our cells face cause aging

for example, in the face

but also to our muscles

how cells work

everything starts in stem cells

every organ has its own stem cells

stem cells are very good in diviving

one stem cell

multiple daughter cells

daughter cells can rapidly produce tissue

when you lose tissue

stem cells divide

generates some new tissue

for example, in a 40 year old liver you can have some new cells

stem cells helps us to live for 80 years or longer instead of a couple of months

Idea: how about harvesting stem cells?

in the lab

culture them in a dish

expand their numbers in a dish

then give them back to patients who need them

as part of a new organ

for example, liver, heart, brain

dogma: this is impossible

normal cells in the lab will never expand their numbers

started research in stem cells

50 years ago

in the lab

focusing on the gut

why the gut?

the cells in the gut are exposed to a harsh environment

the cells only live for a few days, they renew every 4 days

the gut should harbor the champion of the stem cells

how it works

a flow of cells comes out of the crypt to the villus

who found out about this?, most of the work was done by Nick Barker, British scientist, now runs own lab in Signapore

How the research turned out

used a molecular flag

used the flag to discover cells

LeBlond cells

tried to prove if these LeBlond cells were the stem cells of the gut

needed to prove two things, the stem cells needed to live as long as its owner, the stem cells need to make all cell types of its organ

need to take a couple of steps

make changes in genetic code, using the Human Genome Project

create a 'knock-out mouse' using these changes, borrowing characteritics from a Firely, borowwing some characterictis from a virus

allows new cells to turn up blue


the stem cells became like fireflies and emitted green light

the daughter cells turned out blue

then captured the stem cells, using a cell sorter machine

created a little tube with about 200,000 stem cells

the next steps

use the stem cells instead of whole organs for donor transplantation

what happened

did some more work with mice

growing a mini gut from a single stem cell, Toshiro Sato, Tokyo

what will happen

will work for humans as well

for, lung, live, pancreas, stomach, intestine

almost any disease will be cured with stem cells