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Cell (2007)_Allingham, Gilbert et al._Vik1, Kar3 by Mind Map: Cell (2007)_Allingham, Gilbert et al._Vik1, Kar3
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Cell (2007)_Allingham, Gilbert et al._Vik1, Kar3

Kar3

N-terminal region for cargo-binding

Role in karyogamy and vegetative growth

One of 6 kinesins in s. cerev.

Forms heterodimer in vivo

Question: Should we not think of Kar3 as the "special" part of the heterodimer, but rather as a general motor adapter for proteins like cik1 or vik1?

Cik1

In absence of vik1, localizes Kar3 along length of spindle

Vik1

Localizes kar3 to spindle poles

similar to catalytic motor core of kinesin, but lacks ATP-binding site

Kar3/Vik1 binds MT cooperatively and stabilizes MTs

They speculate that it may have evolved from common ancestor with kar3

Role at spindle is maybe to focus and crosslink MTs @ spindle

Has analagous neck region to NCD

Is it new information that it might bind MTs?

Skeptical of the 54% result

Authors

John. S. Allingham

Lisa R. Sproul

Ivan Rayment

Susan P. Gilbert

In kinesins, nucleotide binding pocket is highly conserved

NCD may only bind with one head

Other Questions that occurred to me

What would happen if make fusion protein of dimer of kinesin 14 and kinesin-1? (not chimeric monomers, but each motor linked by a flexible linker perhaps)

What about expressing kinesin-1 dimers?

Apryase