Targeted therapy

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Targeted therapy by Mind Map: Targeted therapy

1. Tyrosine kinases (TKs)

1.1. Tyrosine kinase inhibitors (TKIs)

1.1.1. Sunitinib (Sutent)

1.1.2. Sorafenib (Nexavar)

1.1.3. Cabozantinib (Cometriq)

1.1.4. Pazopanib (Votrient)

1.1.5. Axitinib (Inlyta)

1.1.6. Lapatinib (Tykerb, Tyverb)

1.1.7. Vandetanib (Caprelsa)

1.1.8. Nintedanib (Vargatef)

1.1.9. Regorafenib (Stivarga)

1.1.10. Foretinib

1.1.11. Lenvatinin

1.1.12. Motesanib

1.1.13. AP26113

1.2. EGFR

1.2.1. Cetuximab (Erbitux)

1.2.2. Erlotinib (Tarceva)

1.2.3. Lapatinib (Tykerb/Tyverb

1.2.4. Gefitinib (Iressa)

1.2.5. Dacomitinib

1.2.6. AP26113

1.3. ALK

1.3.1. Crizotinib (Xalkori)

1.3.2. AP26113

1.4. ROS1

1.4.1. Crizotinib (Xalkori)

2. Growth factors

2.1. VEGF

2.1.1. VEGF-A

2.1.1.1. Bevacizumab (Avastin)

2.1.1.2. Ranibizumab (Lucentis)

2.1.2. VEGFRs

2.1.2.1. VEGFR2 - KDR

2.1.2.1.1. Ramucirumab (Cyramza)

2.1.2.2. Cediranib

2.1.3. VEGF Trap

2.1.3.1. Aflibercept

3. IGF-1R

3.1. Figitumumab

4. PI3K

4.1. Alpelisib

4.2. Idealisib

5. PTK2 / Focal adhesion kinase - FAK

6. EZH2

7. DLL4

8. PARP

8.1. Olaparib

8.2. Veliparib

9. Proteasome

9.1. Carfilzomib

10. MAPK

10.1. BRAF

10.1.1. Dabrafenib (Tafinlar)

10.1.2. Vemurafenib (Zelboraf)

10.2. MAP2K1 (MEK1/MEK2)

10.2.1. MEK inhibitors

10.2.1.1. Trametinib (Mekinist)

10.2.1.2. Selumetinib

10.2.1.3. Cobimetinib

10.2.1.4. Binimetinib