Tumoral patterns

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Tumoral patterns by Mind Map: Tumoral patterns

1. Cell patterns

1.1. Cell shape

1.1.1. Cuboidal cells

1.1.2. Columnar cells Clear pale cytoplasm

1.1.3. Polygonal

1.1.4. Round cells Small round cells Small myoid cells or plasmacytoid cells Small round blue cells Large round cells Large myoid cells

1.1.5. Small cells Eccentric, crescentic nuclei

1.1.6. Large cells Ballon cells Abundant pale cytoplasm Abundant eosinophilic cytoplasm

1.1.7. Stellate cells

1.1.8. Spindle cells / Fusiform cells Fibroblastic/Myofibroblastic cells Fibrohistiocytic cells Fibroblastic cells Myofibroblastoma Atypical fibroxanthoma Myofibroblastic sarcoma Fibrous tumor of soft tissue Schwann cells Schwannoma Neurilemmoma Meningioma Adipocytic cells Smooth muscle cells Leiomyoma Leiomyosarcoma Striated muscle cells Rhabdomyosarcoma Melanocytic cells Spitz naevus Melanoma Melanocytoma Epithelial cells Sarcomatoid carcinoma / Carcinosarcoma Endothelial cells Kaposi sarcoma Angiosarcoma Kaposiform hemangioendothlioma Cajal cells GIST Interdigitating dendritic cell sarcoma

1.1.9. Giant multinucleate cells

1.1.10. Cells with giant nuclei

1.2. Cell type

1.2.1. Columnar

1.2.2. Lipocytic

1.2.3. Malpighian

1.2.4. Rhabdoid

1.2.5. Fibroblastic/myofibroblastic

1.2.6. Sebaceous or hibernomatous

1.2.7. Oncocytic / Oxyphilic

1.2.8. Apocrine cells

1.3. Cell appearance

1.3.1. Cytoplasm Scanty Small round blue cells Abundant Eosinophilic Clear / Pale Abundant cytoplasm Eosinophilic / granular Clear cytoplasm In mucinous material Bodies Spherical Eosinophilic Hyaline Rhabdoid

1.3.2. Nuclei Multinucleate cells Frequent Rare Size Small Medium Large Monstruous Shape Round Angulous Irregular Pleomorphic

1.4. Cell appearance

1.4.1. Cell size Small size Small cells Medium size Large size Giant cell Medullary thyroid tumor

1.4.2. Cell shape Round cell Polygonal cell Polygonal or round cells Fusiform cell Spindle cells, irregularly arranged

1.4.3. Sebaceous cells - Hibernomatous cells Sertoli cell tumor

1.5. Nucleus

1.5.1. Chromatin Coarse Fine

1.5.2. Nucleole Marked

1.5.3. Shape Crescentic

1.5.4. Position Central Eccentric

1.5.5. Size Small Medium Large Giant

2. Tumoral stroma or background

2.1. Scant stroma

2.2. Inflammatory stroma

2.2.1. Lymphocytic

2.2.2. Granulomatous

2.3. Fibrous tumors

2.3.1. Desmoplastic tumors

2.4. Myxoid tumors

2.4.1. Soft tissue myxoid tumors

2.4.2. Ectomesenchymal chondromyxoid tumor

3. Architectural patterns

3.1. Trabecular / Cords

3.1.1. Size Slender Single file Palissades cells Broad Trabeculae Round or polygonal cells

3.1.2. Contents Amyloid Medullary thyroid carcinoma Colloid Sweat gland carcinoma Islet cell carcinoma

3.1.3. Behaviour Anastomozing Single file Peripheral palissading

3.1.4. Stroma Inconspicuous Endocrine tumors Fibrosing / Sclerozing

3.1.5. Cells Spindle cells, irregularly arranged Neuroblastoma Wilms tumor Granulosa cell tumor Sertoli cell tumor Small cell carcinoma / Oat cell carcinoma Poorly differentiated carcinoma of the lung Palisading peripheral cells Basal cell carcinoma of the skin Carcinoid tumors Ovarian granulosa cell tumor Sertoli-Leydig cell tumors (Ovarian and testis) Pancreatic Islet cell tumors Pituitary adenoma Cuboidal or columnar clear cells in a mucinous matrix Chordoma Synovial sarcoma Salivary gland tumor Plasmacytoid Oligodendroglioma

3.2. Sheets

3.2.1. Small round cells

3.2.2. Small cells with eccentric nuclei

3.2.3. Large round cells

3.2.4. Large cells with myoid cells Eccentric nuclei and abundant eosinophilic cytoplasm

3.2.5. Spindle cells or Strap cells

3.2.6. Stellate cells

3.3. Hemangiopericytic

3.3.1. Polygonal cells Clear cytoplasm / Central nuclei Vacuolated cytoplasm / Hibernomatous

3.3.2. Lipocytic cells

3.3.3. Eosinophilic cytoplasm Granular cytoplasm Myoid cells

3.3.4. Spindle cells

3.3.5. Round cells

3.3.6. Admixture of multinucleated / osteoclastic cells

3.4. Clefts

3.5. Laceworks

3.6. Papillary

3.7. Comedo pattern

3.7.1. Breast carcinoma

3.7.2. Sweat gland carcinoma

3.7.3. Salivary gland carcinoma

3.8. Mucinous / Colloïd patter

3.8.1. Mucinous carcinoma Colorectal Pulmonary Mammary

3.9. Alveolar

3.10. Lobular or angular

3.11. Compact

3.12. Circular or oval

3.13. Biphasic

3.13.1. With spindle cells

3.13.2. With myxoma areas

3.14. Specific formations

3.14.1. Bone formation

3.14.2. Calcifications Psammomas Calcospherites

3.15. Glandular / Acinar / Adenomatous

3.15.1. Clear cells

3.15.2. Microacinar

3.15.3. Cribriform

3.15.4. Rosettes

3.15.5. Cylindromas

3.16. Intra-epithelial tumor growth

3.17. Condensation about vessels

3.18. Herringbone pattern