Diagnosis of viral infections (from sample to answer)

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Diagnosis of viral infections (from sample to answer) by Mind Map: Diagnosis of viral infections (from sample to answer)

1. Diagnostic process

1.1. sick patient

1.2. specimen

1.2.1. blood Ab (acute IgM, memory IgG) viraemia blood-borne viruses, HIV, arboviruses

1.2.2. tissue and fluids CSF (viral meningitis) faeces (gastroenteritis) biopsies (CMV, rabies)

1.2.3. respiratory nose/throat swab nasopharyngeal aspirates gargle

1.2.4. lesions scrapings vesicle fluid

1.2.5. environmental water/food

1.3. specimen transport

1.3.1. culture

1.3.2. nucleic acid testing (degradation of RNA)

1.3.3. viral transport media

1.3.4. cold chain

1.4. lab test

1.4.1. OPEN virus culture EM PCR

1.4.2. CLOSED specific serology PCR rapid antigen test

1.4.3. sensitivity vs specificity

1.4.4. types of tests culture CPE HA Antigen detection serological IgM and IgG ELISA microscopic EM IF molecular PCR and qPCR DNA sequencing hybridisation techniques

1.5. interpretation

1.6. action

1.6.1. treatment

1.6.2. public health response

2. why diagnose?

2.1. treatment

2.1.1. antiviral therapy

2.1.2. assess effectiveness of treatment

2.1.3. other (abortion, caesarian, vaccination)

2.2. staging of infection (acute, persistent, chronic)

2.3. susceptibility to infection

2.4. infection control

2.5. public health measures (blood supply, travel advisories)

2.6. surveillance

2.7. bioterrorism

2.8. outbreak investigation