Diagnosis of viral infections (from sample to answer)

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Diagnosis of viral infections (from sample to answer) by Mind Map: Diagnosis of viral infections (from sample to answer)

1. Diagnostic process

1.1. sick patient

1.2. specimen

1.2.1. blood

1.2.1.1. Ab (acute IgM, memory IgG)

1.2.1.2. viraemia

1.2.1.2.1. blood-borne viruses, HIV, arboviruses

1.2.2. tissue and fluids

1.2.2.1. CSF (viral meningitis)

1.2.2.2. faeces (gastroenteritis)

1.2.2.3. biopsies (CMV, rabies)

1.2.3. respiratory

1.2.3.1. nose/throat swab

1.2.3.2. nasopharyngeal aspirates

1.2.3.3. gargle

1.2.4. lesions

1.2.4.1. scrapings

1.2.4.2. vesicle fluid

1.2.5. environmental

1.2.5.1. water/food

1.3. specimen transport

1.3.1. culture

1.3.2. nucleic acid testing (degradation of RNA)

1.3.3. viral transport media

1.3.4. cold chain

1.4. lab test

1.4.1. OPEN

1.4.1.1. virus culture

1.4.1.2. EM

1.4.1.3. PCR

1.4.2. CLOSED

1.4.2.1. specific serology

1.4.2.2. PCR

1.4.2.3. rapid antigen test

1.4.3. sensitivity

1.4.3.1. vs specificity

1.4.4. types of tests

1.4.4.1. culture

1.4.4.1.1. CPE

1.4.4.1.2. HA

1.4.4.1.3. Antigen detection

1.4.4.2. serological

1.4.4.2.1. IgM and IgG

1.4.4.2.2. ELISA

1.4.4.3. microscopic

1.4.4.3.1. EM

1.4.4.3.2. IF

1.4.4.4. molecular

1.4.4.4.1. PCR and qPCR

1.4.4.4.2. DNA sequencing

1.4.4.4.3. hybridisation techniques

1.5. interpretation

1.6. action

1.6.1. treatment

1.6.2. public health response

2. why diagnose?

2.1. treatment

2.1.1. antiviral therapy

2.1.2. assess effectiveness of treatment

2.1.3. other (abortion, caesarian, vaccination)

2.2. staging of infection (acute, persistent, chronic)

2.3. susceptibility to infection

2.4. infection control

2.5. public health measures (blood supply, travel advisories)

2.6. surveillance

2.7. bioterrorism

2.8. outbreak investigation