Alzheimer's Disease
by Darren McKenna
1. Loss of brain function
2. Affects Semantic Memories
2.1. New memories affected, understanding and general knowledge tend to be problamatic.
3. Angiopathy
3.1. Veins
3.2. Capilliaries
3.3. Arteries
4. Pathology
4.1. The study of disease
5. Cerebral
5.1. Ischemic
5.1.1. Blood restriction to tissue
5.1.2. Shortage of oxygen
5.1.3. Shortage of glucose
5.2. Hemorrhagic
6. Hypoperfusion
7. Phosphodiesterase
7.1. Enzyme
8. Cerebrovascular
8.1. Hypertension
9. Beta Amyloid
9.1. Proteinaceous
9.2. Amyloid
9.3. Aβ
9.4. Albumoid
9.5. Extracellular
9.6. Oligomer
10. Type 3 Diabetes
11. Blood–Brain Barrier
11.1. Semipermeable membrane
11.1.1. Brainpeps
11.2. Becomes more permeable during inflammation
11.2.1. What causes inflammation?
11.2.1.1. Glial
11.2.1.1.1. Homeostasis
11.2.1.1.2. Myelin
11.2.1.2. Leukocytes
11.2.2. Phagocyte
11.2.3. Virus
11.2.4. Bacteria
11.3. Nanoparticles
11.3.1. Liposome
11.3.1.1. Glucose?
11.4. Disrupted from AD?
11.5. Astrocyte
11.5.1. Glutamates
12. BIIB 037
13. Video
14. Methanesulfonyl Fluoride
14.1. Potentially toxic
14.2. Inhibits enzymes in the brain
14.3. Inhibits stomach enzymes but these do recover faster
14.3.1. Less side effects
15. http://www.alzheimersresearchuk.org
16. Neurofibrillary Tangle
16.1. Tau Protein
17. REMENTIA
17.1. Rehabilitation
17.1.1. Speech-Language Pathology
17.1.2. Occupational Therapy
17.1.3. Eye–Hand Coordination
17.1.4. Cognitive Processes
17.1.5. Neurocognitive