Estimates for the duration of the prodromal phase vary from months to decades. It is concluded that there probably is an early phase in the disease where a variety of nonmotor features develop, but the sequence and time of onset of such features is not well established.
Gastrointestinal dysfunction, One group of healthy individuals and One group of people PD -> ask them about GIT dysfunction, Is the prevalence of GIT dysfunction higher in PD patients?, Cause? Dopaminergic receptors in GIT?
New insights into the pathology of Parkinson's disease: does the peripheral autonomic system become central? http://www.ncbi.nlm.nih.gov/pubmed/18353130
#32 Search #27 AND (#28 OR #31) 11:51:57 2 #31 Search "REM Sleep Parasomnias"[Mesh] 11:50:53 455 #28 Search rem sleep behaviour disorder 11:50:21 642 #27 Search ("Heart Rate"[Mesh]AND "Autonomic Nervous System Diseases"[Mesh])
Does Heart Rate variability differ from patients with a sleep behavior disorder and various PD risk factors with PD patients with a REM sleep behavior disorder?, Part of Answer!
What's the effect of arousal in sleep on heartrate?, Is there a difference in PD patients?, Is this a measure for autonomic nerve system involvement in prodromal phase?
Definition of REM sleep Behavior Disorder
Measurements for REM Sleep behavior disorder, Polysomnography, Simple Heart rate monitoring, Measure: heartrate variability as sign of autonomic nervous system function
Anosmia, Study participant selection, Olfactory testing of partners of PD patients, Additional tests on patients with lowest scores and same number of normal scores as control, Questionnaire evaluation after 5 years for full group
anxiety and panic attacks
mild cognitive impairment
DOPAMINERGIC NEUROTRANSMITION OUTSIDE CNS: http://en.wikipedia.org/wiki/Dopamine_receptor ;)
Lack of a vitamins??
prion like protein activity, Where does this protein cause initial damage?, Which neurons are affected?, Dopamine loss a cause or a result?, Infectious particle or an accidental misfolding which induces prion behaviour
Do we need to?
There's no disease modifying drug
Would physicial exercise be a way to delay motor symptom onset?
Hypothesis: dopaminergic cell loss is a cause of the pathology
Hypothesis: dopaminergic cell loss is a result of pathology
"Early Diagnosis"[Majr] AND "Parkinson Disease"[Majr]