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Non Motor prodromal symptoms by Mind Map: Non Motor prodromal
symptoms
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Non Motor prodromal symptoms

Links

Recognition and Management of Parkinson's Disease during the Premotor (Prodromal) Phase --> http://www.medscape.com/viewarticle/705802

Prospective association between emotional health and clinical evidence of Parkinson's disease --> http://cmk-proxy.mf.uni-lj.si:2068/pubmed/18795943

Nonmotor symptoms as presenting complaints in Parkinson's disease: a clinicopathological study --> http://cmk-proxy.mf.uni-lj.si:2068/pubmed/17994582

Symptoms and duration of the prodromal phase in parkinson's disease --> http://www3.interscience.wiley.com/journal/109747690/abstract?CRETRY=1&SRETRY=0

The prodromal phase of sporadic Parkinson's disease: Does it exist and if so how long is it? --> http://www3.interscience.wiley.com/journal/121392121/abstract

Estimates for the duration of the prodromal phase vary from months to decades. It is concluded that there probably is an early phase in the disease where a variety of nonmotor features develop, but the sequence and time of onset of such features is not well established.

Olfactory testing combined with dopamine transporter imaging as a method to detect prodromal Parkinson’s disease -->

Parkinson's at risk syndrome: can Parkinson's disease be predicted? --> http://cmk-proxy.mf.uni-lj.si:2068/pubmed/20187248

When Does Parkinson Disease Start? --> http://archneur.ama-assn.org/cgi/content/short/67/7/798

known prodromal symptoms

autonomic disorders

Gastrointestinal dysfunction, One group of healthy individuals and One group of people PD -> ask them about GIT dysfunction, Is the prevalence of GIT dysfunction higher in PD patients?, Cause? Dopaminergic receptors in GIT?

cardiovascular dysfunction

New insights into the pathology of Parkinson's disease: does the peripheral autonomic system become central? http://www.ncbi.nlm.nih.gov/pubmed/18353130

sleep disorders

#32 Search #27 AND (#28 OR #31) 11:51:57 2 #31 Search "REM Sleep Parasomnias"[Mesh] 11:50:53 455 #28 Search rem sleep behaviour disorder 11:50:21 642 #27 Search ("Heart Rate"[Mesh]AND "Autonomic Nervous System Diseases"[Mesh])

Does Heart Rate variability differ from patients with a sleep behavior disorder and various PD risk factors with PD patients with a REM sleep behavior disorder?, Part of Answer!

What's the effect of arousal in sleep on heartrate?, Is there a difference in PD patients?, Is this a measure for autonomic nerve system involvement in prodromal phase?

Definition of REM sleep Behavior Disorder

Measurements for REM Sleep behavior disorder, Polysomnography, Simple Heart rate monitoring, Measure: heartrate variability as sign of autonomic nervous system function

sensory dysfunctions

Anosmia, Study participant selection, Olfactory testing of partners of PD patients, Additional tests on patients with lowest scores and same number of normal scores as control, Questionnaire evaluation after 5 years for full group

neuropsychiatric disordes

Apathy

anxiety and panic attacks

mood disturbances

mild cognitive impairment

psychosis

H. pylori: http://www.ncbi.nlm.nih.gov/pubmed/10971237

DOPAMINERGIC NEUROTRANSMITION OUTSIDE CNS: http://en.wikipedia.org/wiki/Dopamine_receptor ;)

Why this topic?

Make a connection with prodromal symptoms and pathophysiological mechanisms

To find possibility to delay onset of motor symptoms

Identify possibilities to start monitoring progress of the disease in an early stage

Sth triggers the process that at first leads to non motor then motor symptoms -> WHAT are the TRIGGERS?

Virus??

Lack of a vitamins??

Autoimmune disease??

prion like protein activity, Where does this protein cause initial damage?, Which neurons are affected?, Dopamine loss a cause or a result?, Infectious particle or an accidental misfolding which induces prion behaviour

why early recognition

Can we start treating non motor symptoms?

Do we need to?

There's no disease modifying drug

Would physicial exercise be a way to delay motor symptom onset?

Can we start studying PD earlier?

Can we identify causal relations with next disease phases?

What is the relative contributing value of each of these symptoms to PD or other dieases

Pre-motor Pathophysiology

There MAY be dopamine loss in this phase

Hypothesis: dopaminergic cell loss is a cause of the pathology

There may not be dopamine loss

Hypothesis: dopaminergic cell loss is a result of pathology

early detection

"Early Diagnosis"[Majr] AND "Parkinson Disease"[Majr]

predicting pd 2009

Diagnosing premotor Parkinson's disease using a two-step approach combining olfactory testing and DAT SPECT imaging.

premotor pd 2008