DENGUE FEVER

1. LABORATORY TEST

1.1. Complete Blood Count

1.1.1. - Leukopenia - Hematocrit and Hemoglobin increased (>10% increase predicts severe disease) - Thrombocytopenia (<100,00cells/mm3 often severe)

1.2. Liver Transaminases

1.2.1. mildly increase

1.3. Dengue IgM (after day 4) Dengue IgG (after day 7)

1.4. Dengue NS1

2. SALIENT FEATURES

2.1. 1 week intermittent moderate grade fever

2.2. Myalgia

3. TREATMENT

3.1. Acetaminophen

3.2. Avoid aspirin and other salicylates

3.3. Avoid NSAIDs

4. MANAGEMENT

4.1. Group A

4.1.1. sent home

4.2. Group B

4.2.1. in-hospital

4.3. Group C

4.3.1. emrgency treatment

5. MODE OF TRANSMISSION

5.1. uninfected A. aegypti mosquito bite an infected person

5.2. infected A. aegypti mosquito bite a uninfected person

6. CAUSATIVE AGENT

6.1. Dengue virus 1, 2, 3, and 4

6.2. Ae. aegypti or Ae. albopictus

7. DEFINITION

7.1. Dengue fever is a disease caused by a family of flaviviruses transmitted by infected mosquitoes.

8. EPIDEMIOLOGY

8.1. widespread throughout the tropics and subtropics

9. PATHOGENICITY

9.1. dengue virus infects immature dendritic cells

9.2. activate the cellular and humural response

9.3. virus replicates in macrophages for 3-6 days (incubation period to viremia)

9.4. symptoms will start following fever

9.5. mosquitoes remain infectious for entire 1-month and can transmit infection