1. Normal Playthrough
2. Kill Everything Playthrough
3. Melee Only Playthrough
4. Unarmed Only Playthrough
5. 100% Playthrough with More Goals
5.1. Complete All Quests (By Location)
5.1.1. Vault 13
5.1.1.1. Find the Water Chip
5.1.1.2. Calm Rebel Faction
5.1.1.3. Find the Water Thief
5.1.1.4. Destroy the Mutant Leader
5.1.1.5. Destroy the Source of the Mutants
5.1.1.6. Obtain More Equipment
5.1.1.7. Research Important Information
5.1.1.8. Unlock the Armory
5.1.2. Shady Sands
5.1.2.1. Rescue Tandi From the Raiders
5.1.2.2. Stop the Radscorpions
5.1.2.3. Talk to Katrina
5.1.2.4. Improve Shady Sands' Agricultures
5.1.2.5. Recruit Ian
5.1.2.6. Make Poison Antidote
5.1.2.7. Cure Jarvis of Radscorpion Poison
5.1.3. Raiders
5.1.3.1. Free the Slaves
5.1.4. Junktown
5.1.4.1. Rescue Sinthia
5.1.4.2. Stop Gizmo
5.1.4.3. Bust the Skulz Gang
5.1.4.4. Save Killian's Life
5.1.4.5. Get Gizmo's Confession
5.1.4.6. Solve Phil's Canine Conundrum
5.1.4.7. Recruit Tycho
5.1.4.8. Help Saul
5.1.4.9. Steal Neal's Urn
5.1.5. Hub
5.1.5.1. Find the Missing Caravans
5.1.5.2. Steal Necklace From the Merchants
5.1.5.3. Ask Water Merchant to Help
5.1.5.4. Blackmail Iguana Bob
5.1.5.5. Help Irwin
5.1.5.6. Guard the Caravans
5.1.5.7. Clean Out the Loan Shark
5.1.5.8. Take Down Decker
5.1.5.9. Rescue Initiate From the Hub
5.1.6. Necropolis
5.1.6.1. Destroy the Super Mutants at the Watershed
5.1.6.2. Fix the Necropolis Water Pump
5.1.6.3. Free Ghoul Prisoner
5.1.7. Glow
5.1.7.1. Turn on Power for the Glow
5.1.8. Brotherhood
5.1.8.1. Become an Initiate
5.1.8.2. Rescue Initiate from the Hub
5.1.8.3. Scout the Northern Wastes
5.1.8.4. Convince the Elders to Send Help
5.1.8.5. Fix the Broken T-51b Power Armor
5.1.8.6. Receive Your Weekly Issue
5.1.8.7. Dr. Lorri's Surgeries
5.1.8.8. Receive Training from Thomas
5.1.8.9. Get Sophia Some Pulse Grenades for Michael
5.1.9. Boneyard
5.1.9.1. Fix the Hydroponic Farms in Adytum
5.1.9.2. Get Weapons for the Blades
5.1.9.3. Exterminate the Deathclaws
5.1.9.4. Free Adytum from the Regulators
5.1.9.5. Recruit Katja
5.2. All Locations Discovered
5.2.1. Boneyard
5.2.2. Brotherhood
5.2.3. Cathedral
5.2.4. The Glow
5.2.5. The Hub
5.2.6. Junktown
5.2.7. Military Base
5.2.8. Necropolis
5.2.9. Raiders
5.2.10. Shady Sands
5.2.11. Vault 12
5.2.12. Vault 13
5.2.13. Vault 15
5.3. Have "Champion" Reputation
5.4. Recruit All Companions
5.4.1. Dogmeats
5.4.2. Ian
5.4.3. Katja
5.4.4. Tandi
5.4.5. Tycho
5.5. Experience All High Luck Random Encounters
5.5.1. Alien Ship
5.5.2. Bob's Pre-Owned Car Mart
5.5.3. Brahmin Herd
5.5.4. Giant Footprint
5.5.5. Nuka-Cola Truck
5.5.6. Unusual Call Box
5.6. One of Every Weapon/Armor/Item
5.6.1. Weapons
5.6.1.1. Unarmed Weapons
5.6.1.1.1. Brass Knuckles
5.6.1.1.2. Power Fist
5.6.1.1.3. Rock
5.6.1.1.4. Spiked Knuckles
5.6.1.2. Melee Weapons
5.6.1.2.1. Cattle Prod
5.6.1.2.2. Club
5.6.1.2.3. Combat Knife
5.6.1.2.4. Crowbar
5.6.1.2.5. Knife
5.6.1.2.6. Ripper
5.6.1.2.7. Sledgehammer
5.6.1.2.8. Spear
5.6.1.2.9. Super Sledge
5.6.1.2.10. Throwing Knife
5.6.1.3. Small Guns
5.6.1.3.1. Pistols
5.6.1.3.2. SMGs
5.6.1.3.3. Rifles
5.6.1.3.4. Shotguns
5.6.1.4. Big Guns
5.6.1.4.1. Minigun
5.6.1.4.2. Flamer
5.6.1.4.3. Rocket Launcher
5.6.1.5. Energy Weapons
5.6.1.5.1. Pistols
5.6.1.5.2. Rifles
5.6.1.6. Throwing
5.6.1.6.1. Flare
5.6.1.6.2. Frag Grenade
5.6.1.6.3. Molotov Cocktail
5.6.1.6.4. Plasma Grenade
5.6.1.6.5. Pulse Grenade
5.6.1.6.6. Rock
5.6.1.6.7. Spear
5.6.1.6.8. Throwing Knife
5.6.1.7. Traps
5.6.1.7.1. Dynamite
5.6.1.7.2. Plastic Explosives
5.6.2. Armor
5.6.2.1. Brotherhood Armor
5.6.2.2. Combat Armor
5.6.2.3. Hardened Power Armor
5.6.2.4. Leather Armor
5.6.2.5. Leather Jacket
5.6.2.6. Metal Armor
5.6.2.7. Power Armor
5.6.2.8. Robes
5.6.2.9. Tesla Armor
5.6.3. Ammunition
5.6.3.1. .223 FMJ
5.6.3.2. .44 Magnum FMJ
5.6.3.3. .44 Magnum JHP
5.6.3.4. 10mm AP
5.6.3.5. 10mm JHP
5.6.3.6. 12 Gauge Shotgun Shell
5.6.3.7. 14mm AP
5.6.3.8. 5mm AP
5.6.3.9. 5mm JHP
5.6.3.10. 9mm Ball
5.6.3.11. BBs
5.6.3.12. Explosive Rocket
5.6.3.13. Flamethrower Fuel
5.6.3.14. Microfusion Cell
5.6.3.15. Rocket AP
5.6.3.16. Small Energy Cell
5.6.4. Consumables
5.6.4.1. Antidote
5.6.4.2. Beer
5.6.4.3. Booze
5.6.4.4. Buffout
5.6.4.5. Fruit
5.6.4.6. Iguana-on-a-Stick
5.6.4.7. Mentats
5.6.4.8. Nuka-Cola
5.6.4.9. Psycho
5.6.4.10. RadAway
5.6.4.11. Rad-X
5.6.4.12. Stimpak
5.6.4.13. Super Stimpak
5.6.5. Holodisks and Notes
5.6.5.1. Ancient Brotherhood Disk
5.6.5.2. Alpha Experiment Disk
5.6.5.3. Captain Maxson's Diary
5.6.5.4. Delta Experiment Disk
5.6.5.5. Encryption Decoder Disk
5.6.5.6. FEV Experiment Disk
5.6.5.7. FEV Research
5.6.5.8. Maxson Log
5.6.5.9. Military Base Security Code
5.6.5.10. Mutant Transmissions
5.6.5.11. Power Armor Specs
5.6.5.12. Regulator Transmission
5.6.5.13. Richard Grey's Audio Diary
5.6.5.14. Sophia's Tape
5.6.5.15. Vault Locations v34.129
5.6.5.16. Vree's Autopsy Report
5.6.5.17. West Tek Records
5.6.6. Skill Books
5.6.6.1. Big Book of Science
5.6.6.2. Dean's Electronics
5.6.6.3. First Aid Book
5.6.6.4. Guns and Bullets
5.6.6.5. Scout Handbook
5.6.7. Miscellaneous Items
5.6.7.1. General Use
5.6.7.1.1. Bag
5.6.7.1.2. Back Pack
5.6.7.1.3. Geiger Counter
5.6.7.1.4. Bottle Caps
5.6.7.1.5. Scorpion Tail
5.6.7.1.6. Water Flask
5.6.7.1.7. First Aid Kit
5.6.7.1.8. Doctor's Bag
5.6.7.1.9. Lock Picks
5.6.7.1.10. Electronic Lock Pick
5.6.7.1.11. Motion Sensor
5.6.7.1.12. Stealth Boy
5.6.7.1.13. Tool
5.6.7.2. Quest Items
5.6.7.2.1. Blue Pass Key
5.6.7.2.2. Bug
5.6.7.2.3. Chemistry Journals
5.6.7.2.4. COC Badge (Black)
5.6.7.2.5. COC Badge (Red)
5.6.7.2.6. Junk
5.6.7.2.7. Dog Tags
5.6.7.2.8. Necklace
5.6.7.2.9. Psychic Nullifier
5.6.7.2.10. 2043B Radio
5.6.7.2.11. Red Pass Key
5.6.7.2.12. Rope
5.6.7.2.13. Security Card
5.6.7.2.14. Small Piece of Machinery
5.6.7.2.15. Tape Recorder
5.6.7.2.16. Urn
5.6.7.2.17. Water Chip
5.6.7.2.18. Yellow Pass Key
5.6.7.3. Other Items
5.6.7.3.1. Cat's Paw
5.6.7.3.2. Flower
5.6.7.3.3. Fuzzy Painting
5.6.7.3.4. Key Ring
5.6.7.3.5. Key
5.6.7.3.6. Lighter
5.6.7.3.7. Small Duty Box of Some Sort