1. We're now able to create a world where people don't suffer from heart attacks anymore
1.1. however...
1.1.1. we need to futher develop our technique
1.1.1.1. making it available to patients
1.1.1.2. we need to do this in clinical trials
1.1.1.2.1. really expensive
1.1.2. we need someone to help us bring this idea to patients
1.1.2.1. we don't want tthis beautiful solutiion to be put on the shelf
1.2. we need one brave pioneer
1.2.1. to help getting the product into the patients
2. Navigation
2.1. Back to overview map
3. About
3.1. ... this map
3.1.1. Use the + and - buttons to expand/ collapse topics
3.1.2. Hover over the notes icon to read attached notes
3.1.3. Look our for link icons like this one get more information
3.2. ...the author
3.2.1. Benno Naaijkens
3.2.1.1. Interview at TEDxAmsterdam
3.2.1.2. TEDxAmsterdam Award 2013 Winner
3.2.1.3. VU University Medical Center
3.3. ...this talk
3.3.1. Themes
3.3.1.1. Stem cells
3.3.2. Related talks
3.3.2.1. Hans Clevers - Stem cells: Dr Jekyll or Mr Hyde?
3.3.3. Reactions
3.3.3.1. Here all details on 'Dynamics of #StemBells in an ultrasound field', winner of the @TEDxAms Award 2013 => http://www.echocontrast.nl/frames/FinalProgram/Abstracts/58.%20Kokhuis.pdf … #StemBell
3.3.3.2. “@TEDxAms: #TEDxAmsterdam Award 2013: The Winner Is… StemBell #TEDxAms http://mi8.ly/4oqtf5 ” Let's make this real! Crowd sourcing???
3.3.4. view this talk on YouTube
4. Imagine a world...
4.1. ... where people suffering from a heart attack actually get better
4.2. ... these patients no longer die years after their infarction
5. The challenge: Myocardial infarction
5.1. what is it? what happens?
5.1.1. occlusion of an coronary artery
5.1.1.1. see Wikipedia article
5.1.2. a part of the heart dies
5.1.3. scar tissue is formed
5.1.3.1. because the heart cannot regenerate itself
5.1.4. the heart doesn't function as well anymore as it did before
5.1.4.1. scar tissue is very rigid
5.2. consequence
5.2.1. heart failure
5.2.1.1. one of he most devastating diseases in the world
5.2.1.2. affecting at least 100.000.000 people world wide
6. Developed new solution: StemBells
6.1. Combining
6.1.1. Stem cells
6.1.2. microbubbles and ultrasound
6.2. how does it work?
6.2.1. attaching stem cells to microbubbles
6.2.1.1. see this actual image of a stembell
6.2.2. target them specifically to the right place in the heart
6.2.2.1. pushing them via ultrasound
6.3. goal
6.3.1. increase the number of cells in damaged tissue
6.4. results from a recent study
6.4.1. injecting stembells into rats
6.4.1.1. resulting in an 8-fold increase in the number of cells specifically in the right place in the heart
6.4.2. does this lead to a better functioning heart?
6.4.2.1. yes!
6.4.2.2. 70% reduction of the damaged area
7. possbile existing solutions
7.1. usage of stem cells?
7.1.1. stem cells can be any cells
7.1.1.1. so: also heart cells
7.1.2. unfortunately
7.1.2.1. injecting these stem cells into patients didn't work
7.1.2.2. not enough stem cells reached and attached to the damaged areas of the heart
7.2. tried another solution: microbubbles and ultrasound
7.2.1. what is it?
7.2.1.1. smal gass-filled bubbles that you van delivery to any part of the body that you want