1. Stephen Smith MD NWHealthcare.net Agapenutrition.com
2. Lab Testing
2.1. Blood
2.1.1. Common Labs
2.1.1.1. Liver enzymes
2.1.1.2. Ferritin
2.1.1.3. Homocysteine
2.1.1.4. HS Crp
2.1.2. Genetic
2.1.2.1. MTHFR Profile
2.1.3. Nitro Tyrosine
2.1.3.1. Measures oxidative stress
2.1.3.2. Special Lab only
2.1.4. Glutathione
2.1.5. B12
2.1.5.1. May be high
2.1.5.2. body unable to use
2.2. Urine
2.2.1. Heavy Metal Challenge
2.2.2. Urine Organic Acids
2.2.3. Toxin Screen
2.3. Misc
2.3.1. GI Health
2.3.1.1. If GI symptoms present
2.3.2. Food Allergy
3. Detoxification
3.1. Nutritional Plan
3.2. Body Cleansers
3.2.1. InfraRed Sauna
3.2.2. Clay Baths
3.3. Rules
3.3.1. Fix bowel 1st
3.3.2. Do Slowly
3.3.3. Use binding agents in the bowel
4. Toxin Control
4.1. Avoid
4.1.1. Household chemicals
4.1.1.1. Art Scents
4.1.1.2. cleansers
4.1.1.3. Pesticides
4.1.2. Chronic Chemical Exposures
5. Diet
5.1. Avoid
5.1.1. Hydrogenated fats
5.1.2. Processed Foods
5.2. Increase
5.2.1. Vegetables
5.2.2. Fruits
6. Treatment
6.1. Supplements
6.1.1. MB12
6.1.1.1. Not absorbed orally
6.1.1.2. Compounded
6.1.1.3. Inj. every 3 days
6.1.2. Methyl donors
6.1.2.1. DMG
6.1.2.2. TMG (Betaine)
6.1.3. Fatty Acids
6.1.3.1. Fish Oils
6.1.3.2. Flax Seed
6.1.4. Minerals
6.1.4.1. Zinc
6.1.4.1.1. 20 -40mg/day
6.1.4.2. Selenium
6.1.4.3. Magnesium
6.1.5. Vitamins
6.1.5.1. Vit E
6.1.5.2. Vit C
6.1.5.3. Amino Acids
6.1.5.4. B Complex
6.1.6. Herbs
6.1.6.1. Silymarin
6.1.6.1.1. Liver detoxifier
6.2. Medications
6.2.1. Active Forms of Folate
6.2.1.1. MetaNx
6.2.1.2. Neevo
6.2.1.3. Deplin
6.2.1.4. Cerefolin
6.2.1.5. L methyl folate
6.2.1.5.1. Hard to find
7. Types
7.1. 34 variations
7.2. Most Common
7.2.1. 677
7.2.2. 1298
7.2.3. 677 +1298
8. Definition
8.1. Methyl TetraHydro Folate Reductase Deficiency
8.2. Results in slower than nomal methylation processes
8.3. wiki
9. Attributes
9.1. 677
9.1.1. Elevated Homocysteine
9.1.2. Cardio Vascular Disease
9.1.3. Stroke
9.1.4. DVT (deep venous thrombosus)
9.1.5. Peripheral Neuropathy
9.1.6. Still Births
9.1.7. Pre-Eclampsia, Neural tube, cleft lip
9.1.8. Migraine
9.2. 1298
9.2.1. Depression, anxiety, IBS
9.2.2. Fibromyalgia
9.2.3. Chronic Fatigue
9.2.4. Dementia
9.2.5. Schizophrenia
9.2.6. Parkinson's
9.2.7. TetraHydroBiopterin Problems (BH4)
9.2.8. Migraine
9.3. 677&1298
9.3.1. Symptoms of both defects
9.3.2. More Severe
9.3.3. Blood clots
9.4. All have problems
9.4.1. Clearing heavy metals
9.4.1.1. Lead
9.4.1.2. Mercury
9.4.1.3. Aluminum
9.4.2. Symptoms progress with time
9.4.3. Cancer risk increased
9.4.4. Renal failure
9.4.5. Addiction Potential
9.4.5.1. Drugs
9.4.5.2. Video Games
9.4.5.3. Pornography
9.5. Multiple other MTHFR mutations
9.5.1. 677 & 1298 only two commonly tested
9.5.2. for more complete profile
9.6. Aggravating Factors
9.6.1. Heavy metal exposure
9.6.1.1. amalgams
9.6.1.2. vaccines
9.6.1.3. fish
9.6.1.4. aluminum cookware
9.6.1.5. occupational
9.6.2. Poor Diet
9.6.2.1. processed foods
9.6.2.2. hydrogenated fats
9.6.3. Anesthesia
9.6.4. Other Enzyme Defects
9.6.5. Comorbid Disease
9.6.5.1. Diabetes
9.6.5.2. Lymphoma
9.6.5.3. Leiden Factor V
9.7. Helpful Measures
9.7.1. Dietary
9.7.1.1. vegetables
9.7.1.2. berries
9.7.1.3. fruits
9.7.2. Exercise
9.7.3. Music