Stem Cells - E. Melamed
by Paul de Roos
1. Therapeutic strategies in PD
1.1. symptomatic
1.2. neuroprotective
1.3. neuroregenerative
1.3.1. Cellular therapy
1.3.2. gene therapy
2. Functions
2.1. stem cells will become a common and successful therapy for neurological disorders
2.2. Question: when?
2.2.1. Why is it not happening yet?
3. Which stem cells?
3.1. fibroblasts
3.1.1. cause teratomas
3.2. adult stem cells
3.2.1. from bone marrow
3.2.2. Multilineage differentiation
3.2.3. Aims
3.2.3.1. cell replacement
3.2.3.2. cell restoration
3.2.3.3. neurogenesis
3.2.4. How to use?
3.2.4.1. isolate mesenchymal cells
3.2.4.1.1. differentiate to dopamin producing neurons
3.2.4.1.2. convert to astrocytes
3.2.4.2. Graft
3.2.4.2.1. transplant fully differentiated cells
3.2.5. Biomedical start up company
3.2.5.1. Petah Tikvah
3.2.5.2. autologous stemcell transplantation
3.2.5.3. safety data is gathered for ALS