Cannabinoid system

1. Exogenous cannabinoids

1.1. THC

1.1.1. Synthetic, hydrophilic analogue of THC: [3H]CP-55,940

1.1.2. Synthetic cannabinoid: HU-210 800x more potent than THC

1.2. CBD

2. Ways to detect ECS

2.1. Ligand assay

2.2. Behaviour assay

2.3. Genetic profiling

3. Cannabinoid signalling system

3.1. G protein coupled receptors

3.1.1. CB1 - in Brain cells

3.1.1.1. Antagonist "a substance which interferes with or inhibits the physiological action of another"

3.1.1.1.1. CB1 antagonist: SR141716A

3.1.2. CB2 - in Immune cells

3.1.2.1. CB2 antagonist: SR144528

4. Endogenous CB system

4.1. Receptors

4.2. Endogenous cannabiniods

4.2.1. Ligand 1: Anandamide

4.2.1.1. Hydrolyzed by FAAH

4.2.2. Ligand 2: 2-arachidonylglycerol

4.3. Enzymes

4.4. TRPs??