Evidence based medicine

1. 4R

1.1. Rationale

1.2. Randomized Evidence

1.3. Reproducibility

1.4. Reality

2. Level of evidence 2

2.1. Strong, moderate, optional

3. Steps of Clinical trials

3.1. Clinical

3.1.1. Phase 1

3.1.2. Phase 2

3.1.3. Phase 3

3.2. Pre-clinical

3.3. Drug approval

3.4. Surveillance Phase 4

4. Level of evidence 1

4.1. I

4.2. IIa

4.3. IIb

4.4. III