1. Cell Wall Synthesis: PBP's (penicillin binding proteins)= most prominent target
1.1. Peptidoglycan synthesis
1.1.1. Bacitracin
1.1.2. Vancomycin
1.1.3. Teicoplanin
1.2. Peptidoglycan Corss-linking: BETA LACTAMS
1.2.1. Penicillinase-sensitive penicillins
1.2.1.1. Amoxicillin
1.2.1.2. Ampicillin
1.2.1.3. Penicillin G, V
1.2.2. Penicillinase-resistant penicillins
1.2.2.1. Dicloxacillin
1.2.2.2. Nafcillin
1.2.2.3. Oxacillin
1.2.2.4. Methicillin
1.2.3. Antipseudomonals
1.2.3.1. Piperacillin
1.2.3.2. Ticarcillin
1.2.4. Cephalosporins (I-V):
1.2.4.1. 1st Cefazolin, etc
1.2.4.2. 2nd Cefoxitin, etc
1.2.4.3. 3rd Ceftriaxone, etc
1.2.4.4. 4th Cefepime
1.2.4.5. 5th Ceftaroline
1.2.5. Carbapenems
1.2.5.1. Doripenem
1.2.5.2. Ertapenem
1.2.5.3. Imipenem
1.2.5.4. Meropenem
1.2.6. Monobactams
1.2.6.1. Aztreonam
2. Metabolic Enzymes/folate synthesis
2.1. Sulfonamides
2.1.1. Sulfadiazine
2.1.2. Sulfamethoxazole
2.1.3. Sulfisoxazole
2.2. Trimethoprim
3. Cell Membrane (primary target is Gram negative outer membranes)
3.1. polymixn-B
3.2. Colistin (polymixin-E)
3.3. Gramicidin
3.4. Daptomycin (GRAM POSITIVE)
4. Ribosomes/Protein synthesis
4.1. 50S Subunit
4.1.1. Chloramphenicol
4.1.2. Clindamycin
4.1.3. Oxazolidinones (Linezolid)
4.1.4. Macrolides
4.1.4.1. Azithromycin
4.1.4.2. Clarithromycin
4.1.4.3. Erythromycin
4.1.5. Streptogramins
4.1.5.1. Dalfopristin
4.1.5.2. Quinupristin
4.2. 30S Subunit
4.2.1. Aminoglycosides
4.2.1.1. Gentamicin
4.2.1.2. Amikacin
4.2.1.3. Neomycin
4.2.1.3.1. highest risk of nephrotoxicity
4.2.1.4. Streptomycin
4.2.1.4.1. lowest risk of nephrotoxicity
4.2.1.5. Tobramycin
4.2.2. Tetracyclines
4.2.2.1. Doxycycline
4.2.2.2. Minocycline
4.2.2.3. Tetracycline
5. Nucleic Acid synthesis (DNA replication) - targets topoisomerases
5.1. Fluoroquinolones
5.1.1. Ciprofloxacin
5.1.2. Levofloxacin, etc.