1. Rheumatic disorders (ANA)
1.1. topoisomerase(anti-Sci70) and centromere(ACA)
1.1.1. Thick, ivory skin
1.1.1.1. IgG to vasculature
1.1.1.1.1. Scleroderma
1.2. anti-CCP
1.2.1. RA
1.3. anti-Ro/SS-A or anti-La/SS-B
1.3.1. dry mucosa
1.3.1.1. Sjorgen's Syndrome
1.4. anti-cardiolipin or anti-glycoprotein
1.4.1. thrombosis
1.4.1.1. false positive syphilis test
1.4.1.1.1. APLS
1.5. Anti-dsDNA, anti-Smith, self-macromolecules
1.5.1. SLE
2. Type II: Ab to cell surface/ECM
2.1. Direct Coomb's and C1
2.1.1. hemolytic anemia
2.2. anti-GP2a/3b and vWF cleaver
2.2.1. Idiopathic Thrombocytopenic Purpura
2.3. anti-desmoglein
2.3.1. blistering
2.3.1.1. Pemphigus vulgaris
2.4. TSHR agonist
2.4.1. Bulging eye syndrome
2.4.1.1. Grave's disease
2.5. anti-AChR
2.5.1. diplopia and ptosis
2.5.1.1. Myasthenia gravis
2.6. Molecular mimicry
2.6.1. Group A strep. to heart
2.6.1.1. Rheumatic fever
2.6.2. Campylobacter jejuni to gangliosides(myelin)
2.6.2.1. ascending symmetrical weakness of limbs
2.6.2.1.1. Guillain Barre Syndrome
2.6.3. after infection - neutrophil cytoplasm (ANCA)
2.6.3.1. rhinitis and conjunctivitis
2.6.3.1.1. Granulomatosis with Polyangitis
3. Type III: Immune Complex (reduced C1)
3.1. cryoglobulin/Bence Jones protein - like RF
3.1.1. Mixed essential cryoglobulinemia
3.2. IgG to S.Viridians in heart
3.2.1. Subacute Bacterial Endocarditis
4. Type IV: T-cell
4.1. CD8 to Beta cells of Pancreas
4.1.1. T1DM
4.2. Th1 to myelin - IgG in CSF
4.2.1. progressive muscle weakness; loss of coordination
4.2.1.1. Multiple Sclerosis