1. Solid Tumors
1.1. Small Round Cell tumors
1.1.1. Lymphoma
1.1.2. Neuroblastoma
1.1.3. PNET/Ewing Sarcoma
1.1.3.1. Sarcoma = CA arising from Muscle, bone, fat, fibrous tissue, PNS, & Vessels
1.1.3.2. 85% of Ewing tunors w/ t(11;22)--> oncogenic chimera...
1.1.4. Rhabdomyosarcoma (RMS)
1.1.4.1. Mesechymal tumor, varying degrees of striated muscle differentiation
1.1.4.1.1. E-RMS = Embryonal
1.1.4.1.2. A-RMS= Alveolar
1.1.5. Synovial Sarcoma
1.1.5.1. t(X;18)& SSX1, SS18, SSX2, SSX4
1.1.6. Desmoplastic Small Round Cell Tumor
1.1.6.1. t(11;22)
1.1.7. Clear Cell Sarcoma
1.1.7.1. t(12;22)
1.2. Liposarcoma
1.2.1. Mixoid Round Cell Liposarcoma
1.2.1.1. t(12;16)
1.3. Low Grade Fibromixoid Sarcoma
1.3.1. t(7;16)
1.4. ExtraSkeletal Myxoid Chondrosarcoma
1.4.1. t(9;22)NR4A3 / EWSR1
2. Solid Tumors
2.1. Lymphoma. 90% are B cell
2.1.1. Nonhodgkins Lymphoma
2.1.1.1. Mature Peripheral B cell CA
2.1.1.1.1. Follicular Lymphoma
2.1.1.1.2. Burkitts Lymphoma
2.1.1.1.3. MALT
2.1.1.1.4. ALK+ Lg B cell Lymphoma
2.1.1.1.5. Small Lymphocytic Lymphoma, aka - CLL
2.1.1.1.6. Mantle Cell
2.1.1.1.7. MM
2.1.1.1.8. MGUS
2.1.1.2. Precursor B cell
2.1.1.2.1. B-ALL
2.1.2. HodgkinsLymphoma= Reed Sternberg Cells
3. If chromo del- likely del TS or miRNA that targets oncogene transcripts
4. Blood CA
4.1. Leukemia - (11q23 rearrangements are prominent - MLL gene)
4.1.1. Acute
4.1.1.1. ALL
4.1.1.1.1. Poor Px: t(9;22), 11q23, Hyperdiploidy. Good Px: 12;21, & hyperdiploidy. t(1;19) is another subtype
4.1.1.2. AML
4.1.1.2.1. Good Px w/ t(15;17), inv 16, t(8;21),
4.1.1.2.2. Poor Px = Inv 3, t(6;9), t(9;11)
4.1.2. 5 q abnlty
4.1.2.1. MDS
4.1.2.1.1. 50% w/ cytogeneitc chnages
4.1.2.1.2. BM blasts @ < 20%, but somewhat hypercellular
4.1.2.1.3. Good Px = nl karyotype, Y-, 5q del, 20q del. Don't always have 5q-
4.1.2.1.4. Childhood MDS-Monosomy 7 worse Px then +8 or nl karyotype
4.1.2.2. 5q Syndrome
4.1.2.2.1. del of 5q as only abnlty
4.1.2.2.2. Females have good Px, hypo or nl marrow cellularity
4.1.2.2.3. blasts <5%
4.1.3. Chronic
4.1.3.1. CLL
4.1.3.1.1. -6, -11, -13 (inc freq), -17 (p53 on this chromo - worst Px)
4.1.3.2. CML
4.1.3.2.1. Philidelphia Chromosome t(9;22)- ABL/BCR
4.1.3.2.2. Gleevec