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Fahnestock, Canada by Mind Map: Fahnestock, Canada
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Fahnestock, Canada

Pathways mediating BDNF regulation and cognitive impairment in AD

It's lower in AD patient

correlated with MMSE scores

BDNF in mice studies

mediator in learning and memory

BDNF gene

Complex regulation

Complex transcripts, tissue specific, context specific

In AD 1,2,4 and 6 ou of 9 transcripts is down regulated in AD

Possible pathway for BDNF down-regulation

BDNF mRNA is decreased in Tauopathies

GSK-3beta mediates Abeta-induced BDNF down regulation

How to increase BDNF expression?

BDNF injections can lead to hyperexcitability and epileptiform activity

continuous BDNF infusion down-regulates TrkB, leading to less sensitivity of receptor

The canine model of human aging

brains of aged dogs accumulate beta amyloid,

canine Abeta has teh same amino acid sequence as humans

Papers, Milgram et al 2002, Cotman et al 2002, ..., Fahnestock et al 2010 neuobiol, aging

Amyloid cascade hypothesis

Loss of trophic support

Brain derived neurotrophic factor