CHAPTER 14: Chemistry (N&P)

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CHAPTER 14: Chemistry (N&P) by Mind Map: CHAPTER 14: Chemistry (N&P)

1. Organic Compounds

1.1. Big 4:

1.1.1. carbon

1.1.2. hydrogen

1.1.3. nitrogen

1.1.4. oxygen

1.2. Hydrocarbons: Carbon with H- attached

1.2.1. saturated alkanes (only single bonds) burn readily, react with halogens methane ethane: most common KNOW THESE!!

1.2.2. unsaturated alkenes (double bonds) hexene (6 carbon, double bond) alkynes (triple bonds)

1.2.3. alkyls: hydrogens omitted reactive, bond to functional groups

1.3. Radicals

1.4. Isomers

1.4.1. Stereoisomers identical formulas, different spatial arrangement (enflurane, isoflurane): different halogen substitutions, same chemical formula and atomic weight, diff structures and characteristics (vapor pressure, MAC, blood gas solubility) optical isomers: bend light due to group attached to carbon geometrical isomers: 2 carbons with double bond - no axial rotation

1.4.2. Structural Isomers differ in chemical and physical properties

1.5. Functional Groups: atoms bonded together specifically defining chemical and physical properties

1.5.1. Alcohols (ROH), very polar, dissolves other polar molecules

1.5.2. Phenols (ROH) Simple phenol is polar Complex phenol NOT water soluble (propofol)

1.5.3. C=O: carbonyl group - polar key component in aldehydes, ketones, carboxylic acids, esters, amides

1.5.4. R or R': attached hydrogen or hydrocarbon side chain

1.5.5. 2 parts carbon backbone relatively inert one or more functional groups define properties of compound

1.5.6. Organic Compounds Halogens: F, Cl, Br, I R-X (x = any halogen atom) halogen compounds: most inhaled anesthetics derived from straight chain hydrocarbons or ether compounds Ethers (ROR): highly flammable organic oxides, 2 radical groups, 1 Oxygen (functional group) diethyl ether replaced with nonexplosive halogenated ethers Esters (R-COO-R) form by interacting alcohol with acid anesthetic compounds: esters of para-aminobenzoic acid Amides (-CONH2) related to carboxylic acids - urea class of local anesthetics Amines: R-NH2 derivatives of ammonia, functional group - Nitrogen primary, secondary, tertiary (depending on how many Hydrogen atoms replaced by radical) Physiological active amines Aromatic Compounds: most common formation - benzene ring C6Hc replacing hydrogen with radical creates new compund

2. Elements necessary for human life

2.1. Electrical balance of body fluids

2.1.1. Sodium

2.1.2. Potassium

2.1.3. Chlorine

2.1.4. Phosphorus (neutrality of fluids)

2.2. Bones/teeth/growth

2.2.1. Calcium (strengthens bones, clotting, muscle contraction)

2.2.2. Magnesium (enzymes, nerve/muscle action, present in bones/teeth)

2.2.3. Copper (strengthens bones, enzyme action, formation of hemoglobin)

2.2.4. Manganese ( present in bone forming enzymes, fat and carb metabolism)

2.2.5. Zinc (necessary for normal growth)

2.2.6. Flourine (reduces cavities)

2.3. Other

2.3.1. Sulfur (protein structure)

2.3.2. Chromium (increase insulin effectiveness)

2.3.3. Cobalt (part of B12)

2.3.4. Iodine (thyroid function)

2.3.5. Iron (ion on hemoglobin - attach O2)

2.3.6. Molybdenum (activity of certain enzymes)

3. Bond Breaking

3.1. Break - Energy consumed; Formed - energy released

3.1.1. ATP conversion to ADP (energy consumed)

3.2. Enthalpy: total amount of energy possessed by system

4. Atoms

4.1. Atomic Structure

4.1.1. Nucleus neutron (neutral) protons (+)

4.1.2. Electrons (-) Electron Configuration Electron shells K(2), L(8), M(18), N(32), O(32), P(18), Q(8) Subshells: s(2), p(6), d(10), f(14), g(18) 2-8-8 configuration Octet: most stable with 8 electrons in outer shell (or 2 for He) noble gases Ions: +/- electron. Anion (-) Cation (+) Isotopes: same protons, different neutrons, different mass

4.2. Dalton's Atomic Theory

4.3. Elements

4.3.1. identity/atomic number - protons Periodic Table KNOW THESE!

4.3.2. atomic weight: protons+neutrons

4.3.3. pure substance

4.4. Compounds

4.4.1. pure substance, 2 or more elements fixed ratio of atoms

4.4.2. Mixtures: combination of pure substances

5. Molecule: tightly bound group of atoms act as unit

5.1. Chemical Bonds

5.1.1. Covalent Physical sharing of electrons, stronger octet rule Compounds composed of non-metals tend to be molecular

5.1.2. Electrostatic: "opposites attract" Ion-Ion strongest, not directional, occur anywhere along outer shell, high melting and boiling (NaCl) Ion-Dipole uneven distribution of e- (water) occurs between ion and polar molecule Dipole-Dipole water: weak bonds, polar sides bond with ions - good solvent attraction between opposite partial charges of polar molecues Hydrogen bonding dipolar interaction, stronger than dipole-dipole most important - holds water together in liquid state London forces instant dipole when e- unevenly distributed

5.1.3. Bonding Representations Lewis (electron dot structure) Valence Shell Electron Pair Repulsion

5.1.4. KNOW!!

6. Matter

6.1. gas: no volume, no shape, expand infinitely

6.1.1. steam

6.2. liquid: have volume, assume container shape

6.2.1. water

6.3. solid: have volume, shape, cannot be compressed

6.3.1. ice

6.4. plasma: mixture of ionized gas and free floating e-