Antiepileptic drugs

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Antiepileptic drugs by Mind Map: Antiepileptic drugs

1. Primarily generalized seizures are those in which there is no evidence of localised onset, both cerebral hemispheres being involved from the onset

2. The discharge may spread and become generalized

3. Febrile seizures and infantile spasms are unclassified forms of seizures

4. Partial seizures

4.1. -simple partial (jacksonian) -complex partial (psychomotor or temporal lobe epilepsy)

5. Generalized seizures

5.1. -tonic clonic (grand mal) -absense (petit mal) -myoclonic seizures -tonic seizures -atonic seizures -clonic seizure

6. Mechanism of Antiepileptic drugs

6.1. https://vimeo.com/185355664

6.2. Inhibition of Use Dependent Na+ Channels

6.2.1. Inhibit Na+ channels

6.2.1.1. Phenytoin Carbamazepine Valproate Topiramate Lamotrigine Lacosamide

6.3. Increase in Inhibitory Neurotransmission

6.3.1. Activate GABAA receptors by binding to GABA-BZD-Cl- channel complex

6.3.1.1. Barbiturate Benzodiazepines

6.3.2. Activate GABAA receptors by binding to binding to different site

6.3.2.1. Ganaxolone

6.3.3. the GABA release

6.3.3.1. Gabapentin

6.4. Inhibition of Use Dependent Na+ Channels

6.4.1. Phenytoin Carbamazepine Valproate Topiramate Lamotrigine Lacosamide

6.5. Inhibition of Use Dependent Na+ Channels

6.5.1. Phenytoin Carbamazepine Valproate Topiramate Lamotrigine Lacosamide

7. A chronic disease in which seizures result from the abnormal discharge of cerebral neurones

8. Epilepsy is the condition characterized by recurrent episodes of seizures

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11. Lennox Gestaut syndrome is a form of epilepsy with impaired cognitive function

12. Partial (focal) seizures begin at a specific locus in the brain and may be limited to clonic jerking of an extremity