1. NEURAL RETINAL DEVELOPMENT
1.1. different neuronal types
1.1.1. photoreceptors
1.1.2. cell bodies of ganglion cells
1.1.3. bipolar neurons
1.1.4. Muller glial cells
1.1.5. amarcine neurons
1.1.6. horizontal neurons
1.2. Striated laminar pattern due to cell division,migration and death
1.3. neuroblast precursor cell generated in retinal germinal layer
1.3.1. gives rise to 3 types of neurons or 2 types of neurons and one glial cells
1.3.1.1. beta galactosidase experiment
1.3.1.1.1. stained muller cells, bipolar neurons ad 5 rods
2. LENS AND CORNEA DIFFERENTIATION
2.1. lens placode and ectoderm contact
2.1.1. lens vesicle induces cornea formation via ectoderm
2.1.2. introcular pressure necessary for proper lens formation
2.1.2.1. pressure maintained by SCLERAL BONES derived from neural crest cells, are inelastic in nature
2.2. CRYSTALLIN
2.2.1. necessary for lens differentiation and its function
2.2.2. under influence of neural retina the inner portion cells of the lens vesicle elongate and differentiate
2.2.2.1. firms lens fibres which grow and synthesize CRYSTALLINS
2.2.2.2. fibres continue to grow and fill up the space in the two layers
2.2.3. leads to extrusion of nucleus
2.3. lens contains 3 regions
2.3.1. anterior zone of dividing epithelium cells
2.3.2. equatorial zone of cellular elongation
2.3.3. posterior and central zone of crystalline forming fibres
3. Dynamics of eye development
3.1. involuting endoderm and mesoderm interaction with head ectoderm to form lens forming bias
3.2. precise spatial relationship of lens and retina
3.2.1. optic vesicle
3.2.1.1. forms Optic cup
3.2.1.1.1. 2 layers
3.3. lens placode formation due to optic vesicle and diencephelon
3.3.1. forms the lens
4. TRANSCRIPTION FACTORS expressed in the most anterior tip of the neural plate
4.1. Six3
4.2. Pax6
4.2.1. extremely important in development of the eye
4.2.2. RETINAL GANGLION CELLS are neurons whose axons send electrical impulses to the brain
4.2.2.1. axons meet at optic stalk later called optic nerve
4.3. Rx1
4.4. sonic hedgehog
4.4.1. important for the seperation of the eye field from single to bilateral
4.4.1.1. mutation leads to CYCLOPIA