6. Leukemia-predisposing conditions
создатель Ding Weihao
1. Leukemia
1.1. accounts for 30%~ Paeds cancer
1.2. most sporadic
2. What is the difference between AML and ALL?
2.1. AML and ALL are the two main types of acute leukaemia. The difference between them is the type of white blood cell affected.
3. Leukemia-predisposing conditions
3.1. Single genes
3.1.1. PAX5
3.1.2. CEBPA
3.1.3. ETV6
3.1.4. GATA2
3.2. Cancer syndrome
3.2.1. LFS
3.2.1.1. low hypodiploid B-ALL
3.2.2. CMMRD
3.2.2.1. ALL & AML
3.3. chr instability syndromes
3.3.1. FA
3.3.2. Nijmegen
3.3.3. AT
3.3.4. Bloom
3.3.5. DKC
3.3.6. Shwachman-Diamond
3.3.7. Diamond-Blackfan syndrome
3.4. RAS-opathies
3.4.1. NF1
3.4.2. Noonan
3.5. Aneuploidy
3.5.1. T21
3.5.1.1. acute megakaryocytic leukemia
4. PAX5
4.1. AD, reduced penetrance
4.2. B-ALL in childhood
4.3. no screen recommendation
5. CEBPA
5.1. AD
5.2. AML
6. LFS
6.1. low hypodiploid B-ALL
7. ETV6
7.1. B-ALL (MDS, AML, MM)
8. GATA2
8.1. AD
8.2. symptoms
8.2.1. MDS -> AML
8.2.1.1. MDS: myelodysplasia - bone marrow cells do not develop into mature blood cells
8.2.1.1.1. (so has to develop into AML)
8.3. co-morbidity
8.3.1. HPV and Epstein-Barr virus infection
9. Mnemonic
9.1. Pc LEg
9.1.1. Always Sitting in front of PC, LEg has no muscle; Exposed to radiation, got Leukemia
9.1.2. P,L,E: ALL
9.1.3. c, g: AML
10. Surveillance
10.1. refer to specialist
10.2. educate on signs of leukemia
10.2.1. cheek "rash"
10.2.2. fatigue, fever, brusing, spenomegaly