cell injury: ischemia-reperfussion injury

1. ROS

2. To Do

2.1. carbon monoxide

2.2. lead

2.3. ethanol

2.3.1. FAS

2.4. mercury

2.5. street drugs

2.6. injuries

3. chemically induced liver injury

4. oxidative stress

4.1. membrane damage

4.2. mitochondria

4.2.1. Ca++ overload

4.2.2. permeability

4.2.2.1. transition pore

4.2.3. inefficient antioxidant

4.3. free radicals

4.3.1. lipid peroxidation

4.3.2. produced by

4.3.2.1. metabolism

4.3.2.2. chemicals

4.3.2.3. drugs

4.4. reactive oxygen species ROS

4.4.1. chronic exposure

4.4.1.1. inflammation

4.4.1.2. diabetes

4.4.1.3. autoimmune diseases

4.4.1.4. cancer

4.4.1.5. sterility

4.4.1.6. pathologic

4.5. oxidation of

4.5.1. lipids

4.5.2. proteins

4.5.3. nucleic acids

5. ischemic syndromes

5.1. myocardial

5.2. hepatic

5.3. intestinal

5.4. cerebral

5.5. renal

5.6. brain/stroke