NEONATAL JAUNDICE
作者：FITRI NUR AIN BINTI MAHADZIR
1. PATHOPHYSIOLOGY
1.1. Physiological
1.1.1. Unconjugated hyperbilirubinemia
1.1.1.1. Short lifespan of erythrocytes in the newborn
1.1.1.2. Caused insufficient hepatic billirubin metabolism
1.1.1.3. ↑ Enterohepatic circulation of bilirubin
2. COMPLICATIONS
2.1. Acute bilirubin encephalopathy
2.2. Kernicterus
3. INVESTIGATIONS
3.1. Physical examination for icterus
3.2. Billirubin tests
3.3. Direct and indirect Coombs' test
3.4. Full Blood Count (FBC)
3.5. Liver enzymes test
4. TREATMENT
4.1. Phototherapy
4.2. Exchange transfusions
4.3. IV Immunoglobulin
5. ASSESSMENT
5.1. Assess patient's skin and whites of the eyes-Signs of Jaundice
5.2. Check patient stool
6. DEFINITION
6.1. A yellowish discolouration part of the eyes and skin due to high billirubin levels
7. TYPES
7.1. Pathological
7.1.1. Always unconjugated hyperbilirubinemia
7.1.2. 24 hours after birth
7.2. Physiological
7.2.1. Either conjugated or unconjugated
7.2.2. <24 hours