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LEUKEMIA 作者: Mind Map: LEUKEMIA

1. Blood cancer

1.1. poor prognosis

1.2. Classification

1.2.1. acute

1.2.1.1. AML

1.2.1.2. ALL

1.2.2. chronic

1.2.2.1. CLL

1.2.2.2. CML

2. Risk factors

2.1. Genetic background

2.1.1. Genetic mutations

2.1.1.1. Inherited

2.1.1.2. Acquired

2.2. Environmental factors

2.2.1. mutational agents

2.2.1.1. smoking

2.2.1.2. UV radiation

2.2.1.3. Carcinogenic chemicals

2.3. Commorbidities

2.3.1. Age

2.3.2. Chronic diseases

2.3.2.1. Diabete

2.3.3. Obesity

3. Diagnosis

3.1. Biomarkers

3.2. Sequencing

3.2.1. GWAS

3.2.2. WGS

3.2.3. WES

3.3. Clinical symptoms

4. Blood cells

4.1. Myeloid

4.1.1. erythrocytes

4.2. Lymphoid

4.2.1. leukocytes

4.2.1.1. B cells

4.2.1.2. T cells

5. Treatments

5.1. SWOT

5.1.1. Strengths

5.1.1.1. modern technologies

5.1.1.2. numerous treatments

5.1.1.3. better diagnosis

5.1.2. Weaknesses

5.1.2.1. cost

5.1.2.2. (unknown) side effects

5.1.2.3. resistance

5.1.3. Opportunities

5.1.3.1. personalized treatments

5.1.3.2. quicker care of patients

5.1.4. Threats

5.1.4.1. ethical considerations

5.1.4.2. social discrimination of patients

5.2. Chemotherapy

5.3. Radiotherapy

5.4. Immunotherapy

5.4.1. Monoclonal antibodies

5.4.2. CAR-T cells

5.4.3. Checkpoints inhibitors

5.5. Bone marrow transplant

5.6. Cost

6. Complications

6.1. Relapse

6.2. Infections

6.3. autoimmune disorders

6.3.1. hemolytic anemia

6.3.2. thrombocytopenia

6.4. Development of agressive forms

6.5. Increased risk of cancer

6.6. Resistance