APLASTIC ANEMIA

1. APLASTIC ANEMIA the pathophysiology is a critical condition charecterized by pancytopenia or a reduction of all three blood cells, RBCs, WBCs, platlets resulting in suppression of the bone marrow to produce adequate amount of blood cells. (McCane & Huether, 2014). 2 types of AA. Primary which is 75% of cases, etiology is unknown possible autoimmune. Secondary 15% is related to ionizing radiation, chemical agents.(McCane & Huether, 2014). Infectious agents play a role for example HIV, EPV, Parvovirus with Sickle cell disease. ( McCane & Huether, 2014). See attached Concept MAP.

2. References Bright, R. & Eisendrath (Dec,2014). The International Journal of Psychiatry in Medicine, " A case of factitous Aplastic Anemia. McCance, K. & Huether (2014). Pathophysiology: The biologic basis for disease in children and adults, (7th ed.). St. Louis, MO Mosby, Elsevier. Muir,K. (2013). British Journal of Hematology. The role of occupational and environmental exposures in acquired aplastic anemia.