Effects of Ph and temperature on hemoglobin saturation

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Effects of Ph and temperature on hemoglobin saturation by Mind Map: Effects of Ph and temperature on hemoglobin saturation

1. Environmental factors affecting hemoglobin

1.1. Oxygen reserve(P02)

1.1.1. As the partial pressure of oxygen increases the more readily hemoglobin binds to oxygen

1.2. Blood Ph (7.4)

1.2.1. Bohr effect is a phenomenon that arises from the relationship between Ph & oxygens affinity for hemoglobin: A lower more acidic ph promotes oxygen dissociation from hemoglobin. In contrast a higher or more basic ph inhibits oxygen dissociation from hemoglobin. The greater the amount of carbon dioxide in the blood the more the molecules that must be converted which in turn generates hydrogen ion and lowers blood ph

1.3. Temperature (37'C/98.6 F)

1.3.1. As blood becomes acidic, or blood temp increases carbon dioxide increases in the blood causing more release of oxygen. Example physical exercise, more oxygen is released to skeletal muscles.

1.3.1.1. High temp promotes hemoglobin & oxygen to dissociate faster.

1.4. Metabolic activity within RBcs

1.4.1. 2,3-bisphosphoglycerate(BPG) by erythrocytes =Byproduct of glycolysis because RBC don't have mitochondria, so glycolysis is the sole method by which these cells produce ATP. BPG promotes the disassociation of oxygen from hemoglobin. Therefore the greater the BPG, the more readily oxygen dissociates from hemoglobindespite its partial pressure