Glycopeptides

1. Vancomycin

1.1. many gm+ bacteria

1.2. poorly absorbed orally so it's given IV

1.3. skin/soft tissue + bone/joint infections

1.4. treats staphylococcic caused

1.4.1. nosocomial meningitis (after neurosurgery)

1.4.2. endocarditis (standard therapy)

1.4.3. MRSA

1.5. side effects with rapid infusion

1.5.1. flushing

1.5.2. erythematous reactions

1.5.3. tachycardia

1.5.4. hypotension

2. Teicoplanin

2.1. serious or resistant gm+

2.2. I/M and I/V

2.3. higher binding affinity 90-95%

2.4. longer half life

2.5. effective in treating

2.5.1. skin/soft tissue + bone/joint infections

2.5.2. UTI

2.5.3. lower resp. tract

2.5.4. endocarditis

2.5.5. septicemia

2.6. special side effects

2.6.1. nausea

2.6.2. vomiting

2.6.3. diarrhea

2.6.4. erythema

2.6.5. reare

2.6.5.1. bronchospasm

2.6.5.2. thrombocytopenia

3. side effects

3.1. pain and inflammation

3.2. hypersensitive reactions

3.3. auditory impairment

4. Bleomycin

5. mechanism

5.1. inhibit synthesis of cell wall

5.1.1. binds to D- alanine terminus