DOLLY THE SHEEP

1. ILLNESSES AND DEATH

1.1. 2000 - Jaagsiekte sheep retrovirus (JSRV)

1.2. 2001 - arthritis - successfully treated

1.3. 14th February 2003 - death (euthanasia) - tumours growing in lungs

2. DOLLY NOW

2.1. National Museum of Scotland - Edinburgh

3. DOLLY'S LIFE

3.1. announced: 22nd February 1997

3.1.1. public debate - benefits/dangers

3.2. shorter telomeres

3.2.1. DNA - more damage with aging

3.3. 6 children

3.3.1. first lamb - Bonnie

3.3.2. twins Sally and Rosie

3.3.2.1. -Welsh Mountain ram called David

3.3.3. triplets Lucy, Darcy and Cotton

4. MAKING DOLLY

4.1. The Roslin Institute

4.1.1. led by: Professor Sir Ian Wilmut

4.1.2. scientists, embryologists, surgeons, vets , farm staff

4.2. goal/idea

4.2.1. specialised cell -> a new animal?

4.2.2. a better method for producing genetically modified livestock

4.3. DNA came from mammary cell

4.4. born: 5th July 1996

4.4.1. surrogate mother: Scottish Blackface

4.5. white face - first sign of cloning

5. IMPORTANCE OF DOLLY

5.1. first mammal cloned from an adult cell

5.2. proof - cloning is possible

5.2.1. specialised cells -> exact copy of the animal

5.3. biology and medicine

5.3.1. personalised stem cells (iPS cells)