Human health and disease

1. Autoimmunity

1.1. Rheumatoid arthritis

1.2. Myasthenia gravis

1.3. Hashimoto disease

1.4. Diabetes mellitus type 1

1.5. Multiple sclerosis

1.6. Pernicious anemia

2. Blood cell

2.1. RBC(erythrocytes)

2.2. WBC(leukocyte)

2.2.1. Granular

2.2.1.1. Neutrophils (60-70%)

2.2.1.2. Eosinophils (2-3%)

2.2.1.3. Basophils(.5-1%)

2.2.2. Agranular

2.2.2.1. Lymphocyte (20-25%)

2.2.2.1.1. T-lymphocyte

2.2.2.1.2. B-lymphocyte

2.2.2.2. Monocytes (6-8%)

3. Immuno deficiency disorder

3.1. SCID

3.2. AIDS

3.3. De-george syndrome

3.4. Brutons agammaglibulinemia

4. Immunity

4.1. Innate immunity

4.1.1. Physical barriers(skin,mucus)

4.1.2. Physiological barrier (fever,pH of bd,lysozyme)

4.1.3. Cellular barrier (macrophage, neutrophils)

4.1.3.1. Step of phagocytosis

4.1.3.1.1. Vasodilation

4.1.3.1.2. Adhesion

4.1.3.1.3. Migration

4.1.3.1.4. Chemotaxis

4.1.3.1.5. Phagocytosis

4.1.4. Cytokine barrier (interferon)

4.2. Acquired immunity

4.2.1. Humoral imm

4.2.1.1. (b_ lymphocyte)blood and lymph

4.2.2. T_lymphocyte(cell)

5. Antibody

5.1. IgG(passive immunity to foetus)

5.2. IgA(external sec=colostrum,saliva,ters,mucus)

5.3. IgM(activation of b_ cell)

5.4. IgD(pr on lym..Sur..as recepter activation of b cell

5.5. IgE(allergic response

5.5.1. Hey fever

5.5.2. Asthma

5.5.3. Anaphylactic shock(sec.of hismine in whl bd)

6. Transplantation(MHC)HLA match

6.1. Autograft (one area to another on same individual)

6.2. Isograft( b/w monozygotic twins)

6.3. Allograft (b/w genetically different with in same species)

6.4. Genograft(different species)