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Patent foramen ovale (PFO) and stroke - to close or not to close by Mind Map: Patent foramen ovale (PFO) and stroke - to close or not to close
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Patent foramen ovale (PFO) and stroke - to close or not to close

1. PFO and stroke a meta-analysis of case-control studies

Alsheikh-Ali et al, Stroke 2009

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5. Risk of stroke recurrence

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List of reviews

Mas et al NEJM 2001

2. Is stroke due to paradoxical embolism?

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reference

Proven

Presumed

Venous thrombosis

Hypercoagulable state

Circumstances predisposing to DVT

Valsalva-provoking activity

3. Other potential stroke mechanisms

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paroxysmal Atrial fibrillation

Direct embolisation from thrombi formed locally in the PFO tunnel or in the ASA

Occult stroke cause associated with PFO

etc.. see pic

4. Atrial septal aneurysm

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Reference

6. Options for secondary prevention

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Antiplatelet therapy

Oral anticoagulants

PFO closure

CLOSE RCT

7. Our curent practice

Antiplatelet therapy

Oral anticoagulants

PFO closure

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8. Take home message

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Author of presentation

J.L. Mas

http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=Mas+jl[Author]

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