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GI: Antiparasitic Drugs by Mind Map: GI: Antiparasitic Drugs
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GI: Antiparasitic Drugs

Nitroimidazoles

Metronidazole

MOA, Prodrug oxidizes ferredoxin and NADPH; reduced form disrupts DNA's helical structure

Use, Selectively toxic agains anaerobic and microaerophilic pathogens, Entamoeba histolytica, Mech: Excystatins in sm. intestine; trophozoites migrate to colon, Can cause non-invasive, intestinal, or extra-intestinal Dz, Giardia, Mech: excystation in sm. intestine; trophozoites remain in sm. intestine, Trichomonas vaginalis, Mech: Systemic absorption in lower genital tracts and prostate (in males)

Tinidazole

SE better tolerated

Admin

Oral (good oral bioavailability)

Use

Good for intestinal ulcers and systemic effects; doesn't make it to L. intestine!, Mostly tissuecidal

Not for asymptomatic Amebiasis (lumenal E. histolytica)

All forms of Giardia, Trich. vaginalis (DOC)

SE

Common, Nausea, Metallic taste, Headache

Infrequent, Vomiting, vertigo, insomnia, dizziness, Neuropathy - ataxia, seizures, encephalopathy (rare)

Disulfram-like rxn

Teratrogenic

Red-brown urine

Iodoquinol

MOA unknown

Contains iodine!!

PK

poor oral bioavailability, Lumenicidal only!!!

SE

Anorexia, NVD, abdominal cramps, pruritis ani (itchy ass!)

Iodine toxicity (fever, itching, dermatitis)

Thyroid problems

Subacute myelo-optic neuropathy (SMON), Occurs at high dose; kids more susceptible

Paromomycin

MOA

An aminoglycoside!, Antiparasitic properties unknown

Use

Lumenicidal only!

Use in combo with tissuecidal agent for full coverage

Alternative for Giardia

SE

Kidney and eye tox

All the SE of aminoglycosides, Few effects when used orally

Nitazonide

MOA

Unknown, Interferes w/ pyruvate-ferrredoxin oxidoreductase (PROR) but no DNA mutations

Use

DOC: Giardia, Cryptosporidium

Anaerobic infxns only (PFOR)

New node

Anthelmintics (anti-worms)

Benzimidazoles (BZAs)

Thiabendazole, SE, Smells like asparagus

Mebendazole

Albendazole