During the novel George does not hide his displeasure with Lenny's lack of mental capacity; this could reflect the misunderstanding of mental issues during the 1930s.
The plight of segregation is also displayed through the character Crooks. Crooks is not permitted in the bunk house and is confined to the stable because of the color of his skin.
Curly's wife, throughout the novel does not have the priviledge of a name and is referred to only as an object or possession, Curly's wife.
I feel this theme is the most prevalent throughout the novel
George recognizes that Lenny continually gets him in trouble; however he is most nervous of loneliness. His life would be so easy without Lenny, but also very solitary
Curly’s wife despite the constant flirtation, also is fearful of living the rest of her life as a lonely woman surrounded by the world of men
Candy lives in perpetual fear of outliving his usefulness on the ranch. This is exhibited by his desire to keep his dog alive, despite the fact that the dog is old and serves no purpose.
George and Lenny, despite their differences are bound by companionship
The workers themselves exhibit a camraderie amongst themselves against the times and in some cases against management
Throughout the novel George and Lenny dream of owning their own farm, so they do not have to be in constant search of work. This hope at a better life is the fabric of American society, and although sometimes plans can be great, life, nature sometimes has other ideas.
Both Curly’s wife and Candy have dreams of something more. Curly’s wife wanted a better life away from the farm and travel to the big cities. Candy wanted the security that George and Lenny could give him through the farm. Both characters had to face the realities of life.