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Epilepsy Drugs II by Mind Map: Epilepsy Drugs II
0.0 stars - reviews range from 0 to 5

Epilepsy Drugs II



Partial seizures in adults, Both of the are very serious seizures

Lennox-Gastaut Syndrome in kids


High incidence of aplastic anemia and liver failure, Only used on "compassionate use" basis



Inhibits GABA degradation (GABA transaminase) and reuptake, Increases GABA-mediated inhibition


DLR for infantile spasms and refractory complex partial seizures, CP seizures are notoriously hard to control


30% of pts have vision loss

headache, somnolence fatigue, dizziness



Lennox-Gastaut syndrome


acts on Na channels


somnolence, vomiting

Adjunct drugs (for parital seizures)


Use, Partial seizures, Neuropathic pain

MOA, Slows recovery in Na channels, Inhibits V-G Ca channels, Inhibits Glutamate release

SE, Most common: weakness, diplopia, ataxia, N, irritability, SJS, Teratogen: increase risk of cleft palate, DDI, Inhibits carbarmazepine metab


Use, Partial seizures, Neuropathic pain

MOA, Acts as a subunit of V-G Ca channels to decrease depolarization-induce Ca influx, decreases release of glutatmate (excitatory NT)

SE, somnolence, dizziness, ataxia, fatigue, wt gain, nystagmus, DDI, No major problems!


Use, Partial seizures, Tremors, Migraine prevention

MOA, Blocks Na channels & AMPA/Kainate receptors

SE, Difficulty concentrating, drowsiness, dizziness, ataxia, Wt loss!!!, Increased risk of kidney stones, Inhibits carbonic anhydrase, Measure serum bicarb before starting, Metabolic acidosis may result


SE, somnolence, dry mouth, blurred vision, peripheral edeam, wt gain, Euphoria - Schedule V

Practical aspects of Drug Tx

Status epilepticus

State of continuous seizure activity

Generalized T/C type is 10% fatal

Usually d/t sudden withdrawal of CNS depressants or drug poisoning

Tx, Supportive care, Electrolytes, cardiac arrhythmia, ABCs, Drug, 1) IV diazepam or lorazepam, 2) Maintenance Tx of slow IV phenytoin of PBB infusion, Can't use 1st to prevent CV and CNS collapse


Multiple drug Tx only used if:, >1 seizure type is present, single drug fails to provide adequate control near toxic levels

Remember therapeutic concentration is close to toxic levels for most drugs, watch for signs of toxicity


Use lowest dose that will control seizures

Teratogenic, but uncontrolled seizure also unsafe for fetus

Supplement w/ Vit K and folic acid

Seizure Tx

Grand Mal (Primary generalized Tonic-clonic)

Valproate OR carbamazepine OR phenytoin

Partial (including secondarily generalized)

Valproate OR carbamazepine OR phenytoin

Absence (Petit mal)

Ethosuximide OR Valproate

Atypical absence, myoclonic, atonic