Element 5 Drugs
by Venice Farr
1. Post synaptic acting drugs
1.1. Non-polarising blockers (competitive antagonists) (reversed by anticholinsterases)
1.1.1. D-tubocurarine
1.1.2. Atracurium
1.1.3. Cisatracurium
1.1.4. Mivacurium
1.2. Depolarising blockers (agonist)
1.2.1. Succinylcholine (suxamethonium)
1.3. Anticholinesterases (if too active)
2. Random
2.1. Aspirin
2.1.1. Materials
2.1.2. Personnel
2.1.3. Services
2.1.4. Duration
2.2. Diazepam
2.3. Tetradoxin
2.4. Prozac/Fluoxetine
2.5. Sildenafil/Viagra
3. Presynaptic acting drugs
3.1. Hemicholinium/Triethylcholine
3.2. Vesamicol
3.3. Botulinum toxin (Botox)
3.4. α-latrotoxin
4. Reversible competitive antaganonists
4.1. Propranolol
4.2. Haloperidol
4.3. Atropine
4.4. Ranitidine
4.5. (D-)tubocurarine
5. Parasympathomimetics
5.1. Muscarinic receptor agonists
5.1.1. Selective
5.1.1.1. Cevimeline (M3)
5.1.2. Non-selective
5.1.2.1. Muscarine
5.1.2.2. Bethanechol
5.1.2.3. Carbachol
5.1.2.4. Acetylcholine
5.2. Anticholinesterases
5.2.1. Short acting- Edrophonium
5.2.2. Medium acting- Neostigmine
5.2.3. Irreversible - dyflos
6. Parasympatholytics
6.1. Muscarinic anatagonists (competitive antagonists)
6.1.1. Atropine
6.1.2. Hyoscine
6.1.3. Ipratropium
6.1.4. Pirenzepine
7. Drugs effecting the synthesis of NA
7.1. α-metirosine
7.2. Carbidopa/Benserazide
8. Drugs affecting uptake 1 (NA)
8.1. Tricyclic antidepressants - imipramine
8.2. Cocaine
8.3. Amphetamine, phenoxybenzamine, guanethidine (=noradrenergic neurone blocker)
9. Drugs effecting uptake 2 (NA)
9.1. Phenoxybenzamine
10. Displacing agents (NA)
10.1. Ephedrine
10.2. Pseudoephedrine
10.3. Amphetamine, Metamphetamine, Ecstasy (MDMA)
10.4. Tyramine in food
11. Mixed Agonist (all α and β)
11.1. Adrenaline
12. α1 agonists
12.1. Phenylephrine
12.2. Xylometazoline & Oxymetazoline
12.3. Metaraminol
13. α2 agonists
13.1. Clonidine
13.2. Moxonidine
13.3. Methyldopa (and reduces NA)
14. Mixed β agonists
14.1. Isoprenaline (all β)
14.2. Dobutamine (β1 and α1)
14.3. Dopamine (β1 and α1)
15. β2 agonists
15.1. Salbutamol & Terbutaline
16. Mixed α antagonists
16.1. Phenoxybenzamine = irreversible
16.2. Phentolamine = reversible
17. α1 antagonist
17.1. Prazosin
18. β1 and β2 antagonist
18.1. Propranolol
19. β1 >>> β2 antagonist
19.1. Atenolol
20. α1 and β1 antagonist
20.1. Carvedilol
21. MAO Inhibitors (antidepressants)
21.1. Reversible inhibitors
21.1.1. Moclobemide
21.2. Irreversible inhibitors
21.2.1. Phenelzine
21.2.2. Tranylcypromine
21.2.3. Isocarboxazid